Pegylated interferon beta strongly reduces all serological and intrahepatic hepatitis B virus parameters in immunodeficient humanized mice

被引：0
|
作者：
Pirosu, Andrea [1 ]
Allweiss, Lena [1 ]
Volz, Tassilo [1 ]
Giersch, Katja [1 ]
Petersen, Joerg [2 ]
Luetgehetmann, Marc [3 ,4 ]
Lohse, Ansgar W. [1 ,4 ]
Dandri, Maura [1 ,4 ]
机构：
[1] Univ Med Ctr Hamburg Eppendorf, Dept Internal Med 1, Hamburg, Germany
[2] Asklepios Clin St Georg, IFI Inst Interdisciplinary Med, Hamburg, Germany
[3] Univ Med Ctr Hamburg Eppendorf, Dept Med Microbiol Virol & Hyg, Hamburg, Germany
[4] German Ctr Infect Res DZIF, Hamburg Lubeck Borstel Riems Partner Site, Hamburg, Germany
来源：
JOURNAL OF HEPATOLOGY | 2020年 / 73卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
SAT415
引用
收藏
页码：S860 / S861
页数：2
相关论文
共 17 条
  • [1] PEGYLATED-INTERFERON-ALPHA ALONE OR IN COMBINATION WITH ENTECAVIR RESTORES ISG RESPONSIVENESS AND REDUCES INTRAHEPATIC VIRAL LOADS AND ANTIGENEMIA IN HEPATITIS B VIRUS INFECTED HUMANIZED MICE
    Allweiss, L.
    Luetgehetmann, M.
    Volz, T.
    Bornscheuer, T.
    Lohse, A. W.
    Petersen, J.
    Ma, H.
    Klumpp, K.
    Fletcher, S.
    Dandri, M.
    JOURNAL OF HEPATOLOGY, 2012, 56 : S18 - S19
  • [2] PRETREATMENT OF HUMANIZED UPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HEPATITIS B VIRUS INFECTION
    Volz, T.
    Braunschmidt, J. -L.
    Bornscheuer, T.
    Allweiss, L.
    Lohse, A. W.
    Petersen, J.
    Luetgehetmann, M.
    Dandri, M.
    JOURNAL OF HEPATOLOGY, 2012, 56 : S180 - S181
  • [3] Pegylated interferon alpha treatment rapidly clears Hepatitis E Virus infections in humanized mice
    van de Garde, M. D.
    Pas, S. D.
    van Oord, G. W.
    Gama, L.
    Choi, Y.
    de Man, R. A.
    Boonstra, A.
    Vanwolleghem, T.
    JOURNAL OF HEPATOLOGY, 2017, 66 (01) : S539 - S539
  • [4] Effects of Hepatitis B Virus Infection on the Interferon Response in Immunodeficient Human Hepatocyte Chimeric Mice
    Tsuge, Masataka
    Takahashi, Shoichi
    Hiraga, Nobuhiko
    Fujimoto, Yoshifumi
    Zhang, Yizhou
    Mitsui, Fukiko
    Abe, Hiromi
    Kawaoka, Tomokazu
    Imamura, Michio
    Ochi, Hidenori
    Hayes, C. Nelson
    Chayama, Kazuaki
    JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (02): : 224 - 228
  • [5] Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice
    Wieland, SF
    Guidotti, LG
    Chisari, FV
    JOURNAL OF VIROLOGY, 2000, 74 (09) : 4165 - 4173
  • [6] The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
    Volz, Tassilo
    Allweiss, Lena
    Ben MBarek, Mounira
    Warlich, Michael
    Lohse, Ansgar W.
    Pollok, Joerg M.
    Alexandrov, Alexander
    Urban, Stephan
    Petersen, Joerg
    Luetgehetmann, Marc
    Dandri, Maura
    JOURNAL OF HEPATOLOGY, 2013, 58 (05) : 861 - 867
  • [7] Pretreatment of humanized upa/scid mice with interferon alpha inhibits the establishment of Hepatitis B virus infection but not hepatitis d virus entry
    Luetgehetmann, Marc
    Braunschmidt, Jan-Lukas
    Volz, Tassilo
    Allweiss, Lena
    Giersch, Katja
    Lohse, Ansgar W.
    Petersen, Joerg
    Dandri, Maura
    HEPATOLOGY, 2012, 56 : 423A - 423A
  • [8] Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric Mice
    Reinharz, Vladimir
    Ishida, Yuji
    Tsuge, Masataka
    Durso-Cain, Karina
    Chung, Tje Lin
    Tateno, Chise
    Perelson, Alan S.
    Uprichard, Susan L.
    Chayama, Kazuaki
    Dahari, Harel
    JOURNAL OF VIROLOGY, 2021, 95 (14)
  • [9] Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus
    Tsuge, Masataka
    Uchida, Takuro
    Hiraga, Nobuhiko
    Kan, Hiromi
    Makokha, Grace Naswa
    Abe-Chayama, Hiromi
    Miki, Daiki
    Imamura, Michio
    Ochi, Hidenori
    Hayes, C. Nelson
    Shimozono, Rieko
    Iwamura, Tomokatsu
    Narumi, Hideki
    Suzuki, Tomohiko
    Kainoh, Mie
    Taniguchi, Tadatsugu
    Chayama, Kazuaki
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (06)
  • [10] COMPLETE HEPATITIS C VIRUS ELIMINATION DURING PEGYLATED INTERFERON α2B AND RIBAVIRIN TREATMENT REDUCES THE RISK OF PROGRESSION TO HEPATOCELLULAR CARCINOMA
    Ogawa, E.
    Furusyo, N.
    Kajiwara, E.
    Takahashi, K.
    Nomura, H.
    Tanabe, Y.
    Satoh, T.
    Maruyama, T.
    Nakamuta, M.
    Kotoh, K.
    Azuma, K.
    Dohmen, K.
    Shimoda, S.
    Hayashi, J.
    JOURNAL OF HEPATOLOGY, 2012, 56 : S452 - S452
12