Valproic Acid Enhances the Anti-tumor Effect of Pegylated Interferon-α Towards Pancreatic Cancer Cell Lines

被引：0

作者：

Sugimoto, Koji ^{[1
]}

Shimada, Mitsuo ^{[1
]}

Utsunomiya, Toru ^{[1
]}

Morine, Yuji ^{[1
]}

Imura, Satoru ^{[1
]}

Ikemoto, Tetsuya ^{[1
]}

Iwahashi, Shuichi ^{[1
]}

机构：

[1] Univ Tokushima, Dept Surg, Inst Hlth Biosci, Tokushima 7708503, Japan

来源：

ANTICANCER RESEARCH | 2014年 / 34卷 / 07期

关键词：

Histone deacetylase inhibitor; valproic acid; pegylated interferon-alpha; pancreatic cancer; HISTONE DEACETYLASE INHIBITORS; REGULATORY FACTOR-8; IN-VITRO; COMBINATION THERAPY; IFN-ALPHA; EXPRESSION; APOPTOSIS; ANGIOGENESIS; REGRESSION; CARCINOMA;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Valproic acid (VPA) acts as a specific inhibitor of class I HDACs and it use has been proven to be safe since a long time. Materials and Methods: In the present study, we investigated the effect of VPA in the combination with pegylated interferon-alpha (PEG-IFN alpha) in inhibition of cell proliferation of human pancreatic cancer cell lines. Results: VPA enhanced the effect of PEG-IFNa, and the effect was decreased by the caspase inhibitor. VPA alone and VPA in combination with PEG-IFNa increased the expression of interferon-alpha receptor and interferon regulatory factor 8. Conclusion: The combination of VPA and PEG-IFN alpha can be useful for the treatment of pancreatic cancer.

引用

页码：3403 / 3409

页数：7

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