Flunarizine analgesia is mediated by mu-opioid receptors

被引：4
|
作者：
Weizman, R
Pankova, IA
Schreiber, S
Pick, CG
机构：
[1] TEL AVIV UNIV,SACKLER FAC MED,DEPT ANAT & ANTHROPOL,IL-69978 TEL AVIV,ISRAEL
[2] TEL AVIV UNIV,TEL AVIV COMMUNITY MENTAL HLTH CTR,RAMAT HATAYASSIM & SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL
[3] CHAIM SHEBA MED CTR,DEPT PSYCHIAT C,IL-52621 TEL HASHOMER,ISRAEL
来源：
PHYSIOLOGY & BEHAVIOR | 1997年 / 62卷 / 05期
关键词：
flunarizine; analgesia; opioid receptor subtypes;
D O I：
10.1016/S0031-9384(97)00344-2
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
We evaluated the opioid antinociceptive mechanism of the calcium channel blocker flunarizine. Flunarizine produced a dose-dependent, analgesia in the hot plate test which was antagonized by general (naloxone) and mu [beta-fualtrexamine (beta-FNA)]-opioid antagonists, indicating a role for CL receptors in flunarizine analgesia. Naltrindole (delta(1) antagonist) did not affect flunarizine analgesia. A fixed subthreshold dose of flunarizine augmented mu (morphine) analgesia and blocked delta(1) [enkephalin, [D-Pen(2,5)] (DPDPE)] analgesia. Apparently, flunarizine has mu agonistic activity and delta(1) antagonist or mixed agonistic-antagonistic activity. (C) 1997 Elsevier Science Inc.
引用
收藏
页码：1193 / 1195
页数：3
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