ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolata with their inhibitory activities on LPS-induced NO production in RAW 264.7 macrophages

被引：33
|
作者：
Liu, Zhi-guo [1 ,2 ]
Li, Zhan-lin [1 ,2 ]
Li, Da-hong [1 ,2 ]
Li, Ning [1 ,2 ]
Bai, Jiao [1 ,2 ]
Zhao, Feng [3 ]
Meng, Da-li [1 ,2 ]
Hua, Hui-ming [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
[2] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
[3] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Euphorbia ebracteolata; Ent-abietane diterpenoids; Anti-inflammation; DERIVATIVES;
D O I：
10.1016/j.bmcl.2015.11.080
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ten ent-abietane diterpenoids (1-10), including four new (1-4) and six known ones (5-10) were isolated from the roots of Euphorbia ebracteolata. Their structures were determined by 1D, 2D NMR, and HRESIMS. Compounds 2, 4, and 7 exhibited significant inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 0.69, 1.97, and 0.88 mu M, respectively. A primary structure-activity relationship was also discussed. (C) 2015 Elsevier Ltd. All rights reserved.
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页码：1 / 5
页数：5
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