Polymer-bound TBTU as a new solid-supported reagent for peptide synthesis

被引：37
|
作者：
Chinchilla, R [1 ]
Dodsworth, DJ [1 ]
Nájera, C [1 ]
Soriano, JM [1 ]
机构：
[1] Univ Alicante, Dept Quim Organ, E-03080 Alicante, Spain
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期
关键词：
aminium salts; peptides; polymers; coupling reagents;
D O I：
10.1016/S0040-4039(00)00180-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new polymer-supported TBTU (P-TBTU) has been prepared from polystyrene-bound 1-hydroxybenzotriazole (P-HOBT) and used efficiently as a solid-supported reagent for peptide-coupling reactions, and is even effective with wet solvents. The P-HOBT can be recovered by simple filtration and reused for the preparation of new P-TBTU. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2463 / 2466
页数：4
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