Association of the POLG1 T(-365)C, ANT1 G(-25)A, and PEO1 G(-605)T polymorphisms with diabetic polyneuropathy in patients with Type 1 diabetes mellitus

被引：1
|
作者：
Spitsina, E. V. [1 ]
Svetlova, G. N. [2 ]
Chudakova, D. A. [1 ]
Nikitin, A. G. [1 ]
Kurayeva, T. L. [2 ]
Strokov, I. A. [3 ]
Nosikov, V. V. [1 ]
机构：
[1] State Res Ctr GosNIIgenet, Moscow 117545, Russia
[2] Endocrinol Res Ctr, Moscow 117036, Russia
[3] Sechenov Moscow Med Acad, Moscow 119992, Russia
来源：
MOLECULAR BIOLOGY | 2009年 / 43卷 / 02期
关键词：
diabetic polyneuropathy; POLG1; ANT1; PEO1; association; polymorphic markers; DNA-POLYMERASE-GAMMA; ALPHA-LIPOIC ACID; MITOCHONDRIAL-DNA; PERMEABILITY TRANSITION; ENERGY-METABOLISM; OXIDATIVE STRESS; CELL-DEATH; MUTATIONS; HELICASE; TWINKLE;
D O I：
10.1134/S0026893309020186
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study is dedicated to a search for the association of the polymorphic markers T(-365)C of the POLG1 gene G(-25)A of the ANT1 gene and G(-605)T of the PEO1 gene with diabetic polyneuropathy (DPN) in Type 1 diabetes mellitus (DM1) patients. All patients were ethnic Russian Moscow residents, with DM1 records of no more than 5 years and DPN or DM1 records of more than 10 years but without DPN. We found that the polymorphic marker T(-365)C of POLG1 was associated with DPN in Russian patients with DM1. The carriers of the C allele and the CC genotype had a higher risk of DPN development (OR = 1.62; CI = 1.11-2.38; and OR = 1.76; CI = 0.99-3.13; respectively). In contrast, the T allele carrier status and the TT genotype were associated with a lower DPN risk (OR = 0.62, CI = 0.42-0.90; and OR = 0.61; CI = 0.35-1.07; respectively). We found no association of the polymorphic markers G(-25)A of ANT1 or G(-605)T of PEO1 with DPN in Russian DM1 patients living in Moscow.
引用
收藏
页码：348 / 352
页数：5
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