Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists

被引：6
|
作者：
Laliberte, Sebastien [1 ]
Vallee, Frederic [1 ]
Fournier, Pierre-Andre [1 ]
Bedard, Leanne [2 ]
Labrecque, Jean [3 ]
Albert, Jeffrey S. [4 ]
机构：
[1] AstraZeneca OmegaChem, Dept Med Chem, Montreal, PQ H4S 1Z9, Canada
[2] AstraZeneca, DMPK, Montreal, PQ H4S 1Z9, Canada
[3] AstraZeneca, Dept Biosci, Montreal, PQ H4S 1Z9, Canada
[4] AstraZeneca, Dept Chem, Montreal, PQ H4S 1Z9, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 14期
关键词：
TRPA1; Antagonist; Ligand gated ion channel; CHANNEL; PAIN;
D O I：
10.1016/j.bmcl.2014.05.013
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We describe the discovery and advancement of a novel series of TRPA1 antagonist having an aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamide scaffold. The physical and in vitro DMPK profiles are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3204 / 3206
页数：3
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