Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

被引：32
|
作者：
Rana, Deepti [1 ]
Kumar, Sanjay [2 ]
Webster, Thomas J. [3 ]
Ramalingam, Murugan [4 ]
机构：
[1] Univ Twente, Tech Med Ctr, Dept Biomech Engn, NL-7522 NB Enschede, Netherlands
[2] Christian Med Coll Campus, Ctr Stem Cell Res, Vellore 632002, Tamil Nadu, India
[3] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA
[4] Deemed Univ, Vellore Inst Technol, Ctr Biomat Cellular & Mol Theranost, Biomat & Stem Cell Engn Lab,Sch Mech Engn, Vellore 632014, Tamil Nadu, India
来源：
CURRENT OSTEOPOROSIS REPORTS | 2019年 / 17卷 / 04期
关键词：
Induced pluripotent stem cells (iPSCs); Biomaterials; Osteogenic differentiation; Bone tissue engineering; Bone regeneration; CALCIUM-PHOSPHATE SCAFFOLD; TISSUE; BIOMATERIALS; DESIGN; DEFECT;
D O I：
10.1007/s11914-019-00519-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of ReviewThe main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration.Recent FindingsPluripotent stem cell-based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications.SummaryThis review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.
引用
收藏
页码：226 / 234
页数：9
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