Red hair, MC1R variants, and risk for Parkinson's disease - a meta-analysis

被引：24
|
作者：
Chen, Xiqun [1 ,2 ]
Feng, Danielle [1 ]
Schwarzschild, Michael A. [1 ]
Gao, Xiang [3 ]
机构：
[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, MassGen Inst Neurodegenerat Dis, Boston, MA 02129 USA
[2] Tongji Univ, Sch Med, Shanghai Hosp 10, Shanghai, Peoples R China
[3] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
来源：
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2017年 / 4卷 / 03期
基金：
中国国家自然科学基金;
关键词：
SKIN-CANCER; MELANOMA; NEUROMELANIN; EXPRESSION; RECEPTOR; SURFACE; CORE;
D O I：
10.1002/acn3.381
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.
引用
收藏
页码：212 / 216
页数：5
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