RETRACTED: Expression of an mNSC1 in mammalian cells (Retracted Article. See vol 336, pg 730, 2005)

被引：2
|
作者：
Miyoshi, T
Ooki, G
Murata, M
Hayakawa, H
Tomita, K
Imai, M
Suzuki, M [1 ]
机构：
[1] Jichi Med Sch, Dept Pharmacol, Minami Kawachi, Tochigi, Japan
[2] Kumamoto Univ, Dept Internal Med 3, Kumamoto, Japan
[3] Jichi Med Sch, Dept Cardiol, Minami Kawachi, Tochigi, Japan
[4] Jichi Med Sch, Dept Internal Med 2, Minami Kawachi, Tochigi, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 265卷 / 01期
关键词：
nonselective cation channel; MIN6; beta-cell; niflumic acid;
D O I：
10.1006/bbrc.1999.1622
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have cloned a cDNA inducing a cation-permeable current (mNSC1) from pancreatic beta-cells, which shows niflumate-sensitive current in Xenopus oocytes. To elucidate the expression in mammalian cells, mNSC1 was expressed in CHO cells. The reversal potential by mNSC1 was shifted toward positive which was significantly reversed by flufenamic acid. Single-channel analysis showed a characteristic of a Ca-activated nonselective cation channel. Therefore, we may conclude that mNSC1 expresses a fenamates-sensitive cation channel, inducing membrane depolarization in a mammalian cell. (C) 1999 Academic Press.
引用
收藏
页码：13 / 17
页数：5
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