Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water

被引:24
|
作者
Capurso, A [1 ]
Solfrizzi, V [1 ]
Panza, F [1 ]
Mastroianni, F [1 ]
Torres, F [1 ]
Del Parigi, A [1 ]
Colacicco, AM [1 ]
Capurso, C [1 ]
Nicoletti, G [1 ]
Veneziani, B [1 ]
Cellamare, S [1 ]
Scalabrino, A [1 ]
机构
[1] Univ Bari, Policlin, Ctr Studio Metab Lipoprote, Cattedra Geriatria,Dept Geriatr, I-70124 Bari, Italy
关键词
bile acid excretion; crenotherapy; salt-rich mineral water; serum lipids;
D O I
10.1007/BF03339668
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The effect of a spring mineral water from Montecatini (Italy) on bile acid excretion, and lipid and apolipoprotein serum levels was evaluated. The study was conducted in subjects with serum total cholesterol (TC) level >240 mg/dL and LDL cholesterol (LDL-C) >170 mg/dL, over a 9-week period, with 3 weeks of dietary stabilization, 3 weeks of active treatment, and 3 weeks of tap-water treatment as a control period. Serum lipids and apolipoproteins, total and fractionated bile acid excretion, gallbladder motility, and safety parameters were evaluated. Active treatment with mineral water significantly reduced serum TC by 7.5%, LDL-C by 12.5%, TC/HDL-cholesterol ratio by 6.3%, and apolipoprotein B by 6.3% total fecal bile acid excretion was increased by 98.9%, and gallbladder volume was reduced by 40%. The reduction in serum and LDL-cholesterol levels observed during the active treatment period ran parallel to the increased excretion of bile acids in the stools. We suggest that salt-rich spring water treatment reduces serum and LDL-cholesterol levels in subjects with mild hypercholesterolemia through a mechanism of increased excretion of fecal bile acid sterols. (C) 1999, Editrice Kurtis.
引用
收藏
页码:273 / 276
页数:4
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