Visible-light-mediated one-pot efficient synthesis of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles: a metal-free photochemical approach in aqueous ethanol

被引：7
|
作者：
Nazeef, Mohd [1 ]
Shivhare, Km Neha [1 ]
Ali, Shabir [2 ]
Ansari, Saif [1 ]
Siddiqui, I. R. [1 ]
机构：
[1] Univ Allahabad, Dept Chem, Lab Green Synth, Allahabad 211002, Uttar Pradesh, India
[2] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India
来源：
MOLECULAR DIVERSITY | 2021年 / 25卷 / 04期
关键词：
1-Aryl-1H-3H-thiazolo[3,4-a]benzimidazoles; Green synthesis; Visible light; Metal-free; Ethanol-water; BENZIMIDAZOLES; PHOTOCATALYSIS; SERIES;
D O I：
10.1007/s11030-020-10145-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new metal-free approach to construct medicinally valuable 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles under visible light irradiation in aqueous ethanol medium at room temperature has been developed. The present process was performed with 1,2-phenylenediamines, aromatic aldehydes and 2-mercaptoacetic acid utilizing a simple household 22 W compact fluorescent lamp to generate C-S, C-N bonds through radical intermediates. This visible-light-promoted synthesis provides lower cost, operation simplicity and high functional groups tolerating ability with short reaction time and high yield under mild reaction conditions. [GRAPHICS]
引用
收藏
页码：2479 / 2486
页数：8
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