Synthesis of neplanocin F analogues as potential antiviral agents

被引：31
|
作者：
Zhang, Hongwang
Schinazi, Raymond F.
Chu, Chung K. [1 ]
机构：
[1] Univ Georgia, Coll Pharm, Athens, GA 30602 USA
[2] Emory Univ, Sch Med, Vet Affairs Med Ctr, Atlanta, GA 30033 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 24期
关键词：
D O I：
10.1016/j.bmc.2006.09.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neplanocin F is a natural carbocyclic nucleoside. Herein, we describe the synthesis and antiviral activity of (+/-)-5'-deoxyneplanocin F analogues. The key intermediate 4, synthesized from the commercially available (+/-)-2-azabicyclo[2.2.1]-hept-5-en-3-one (ABH), was utilized to prepare the target nucleosides. Among the target compounds, 5'-deoxyneplanocin F adenine exhibited moderate anti-HIV activity in human lymphocytes without any marked cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8314 / 8322
页数：9
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