Niosomes as carriers of radiopaque contrast agents for X-ray imaging

被引：2

作者：

Muller, D

Foulon, M

Bonnemain, B

Vandamme, TF

机构：

[1] Univ Louis Pasteur Strasbourg 1, Fac Pharm, UMR Pharmacol & Physicochim Interact Cellulaires, F-67401 Illkirch Graffenstaden, France

[2] Univ Louis Pasteur Strasbourg 1, Fac Pharm, Lab Pharm Galen & Pharmacotech, F-67401 Illkirch Graffenstaden, France

[3] Labs Guerbet, Pole R&D Galen, F-93600 Aulnay Sous Bois, France

来源：

JOURNAL OF MICROENCAPSULATION | 2000年 / 17卷 / 02期

关键词：

non-ionic surfactant; drug carriers; niosomes; iobitridol; radiopaque drug delivery;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Non-ionic surfactant vesicles (niosomes) are considered as carriers of iobitridol, a diagnostic agent used for X-ray imaging. The niosomes, with a diameter between 150 and 175 nm, are prepared using the film-hydration method followed by sonication. These vesicles were obtained with appropriate mixtures of D-alpha tocopheryl polyethylene glycol 1000 succinate, polyoxyethylene glycol 4000 stearate, sorbitan monostearate, cholesterol and dicetylphosphate. Methods allowing the increase of the rate of encapsulation and the stability of the vesicles were carried out. In addition to the study of the formulation of the vesicles, the physico-chemical and morphological properties of the vesicles have been studied.

引用

页码：227 / 243

页数：17

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