Poly(iohexol) Nanoparticles As Contrast Agents for in Vivo X-ray Computed Tomography Imaging

被引：85

作者：

Yin, Qian ^{[1
]}

Yap, Felix Y. ^{[4
]}

Yin, Lichen ^{[1
]}

Ma, Liang ^{[1
]}

Zhou, Qin ^{[5
]}

Dobrucki, Lawrence W. ^{[3
]}

Fan, Timothy M. ^{[2
]}

Gaba, Ron C. ^{[4
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Vet Clin Med, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[4] Univ Illinois, Dept Radiol, Chicago, IL 60612 USA

[5] Guangdong Pharmaceut Univ, Dept Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 37期

关键词：

GOLD NANOPARTICLES; DRUG-DELIVERY; CANCER; FORMULATION; POLYMERS;

D O I：

10.1021/ja405196f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanopartides exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.

引用

页码：13620 / 13623

页数：4

共 50 条

[1] Gold nanoparticles as contrast agents in x-ray imaging and computed tomography
Cole, Lisa E.
Ross, Ryan D.
Tilley, Jennifer M. R.
Vargo-Gogola, Tracy
Roeder, Ryan K.
NANOMEDICINE, 2015, 10 (02) : 321 - 341
[2] X-ray computed tomography contrast agents for cartilage imaging
Lusic, Hrvoje
Freedman, Jonathan D.
Snyder, Brian D.
Grinstaff, Mark W.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
[3] Inorganic Nanoparticles Based Contrast Agents for X-ray Computed Tomography
Jakhmola, Anshuman
Anton, Nicolas
Vandamme, Thierry F.
ADVANCED HEALTHCARE MATERIALS, 2012, 1 (04) : 413 - 431
[4] Deoxyglucose Labeled Gold Nanoparticles as X-Ray Computed Tomography Contrast Agents for Cancer Imaging
Li, J.
Rajh, T.
Pelizzari, C.
Chmura, S.
Chaudhary, A.
Wietholt, C.
Redmond, P.
Aydogan, B.
MEDICAL PHYSICS, 2009, 36 (06)
[5] Polymerization-induced self-assembly of large-scale iohexol nanoparticles as contrast agents for X-ray computed tomography imaging
Ding, Yuxun
Zhang, Xinyu
Xu, Yingjin
Cheng, Tangjian
Ou, Hanlin
Li, Zhanyong
An, Yingli
Shen, Wenzeng
Liu, Yang
Shi, Linqi
POLYMER CHEMISTRY, 2018, 9 (21) : 2926 - 2935
[6] Metallic nanoparticles as X-Ray computed tomography (CT) contrast agents: A review
Aslan, Naim
Ceylan, Burhan
Koc, Mumin Mehmet
Findik, Fehim
JOURNAL OF MOLECULAR STRUCTURE, 2020, 1219 (1219)
[7] Tantalum oxide nanoparticles as versatile contrast agents for X-ray computed tomography
Chakravarty, Shatadru
Hix, Jeremy M. L.
Wiewiora, Kaitlyn A.
Volk, Maximilian C.
Kenyon, Elizabeth
Shuboni-Mulligan, Dorela D.
Blanco-Fernandez, Barbara
Kiupel, Matti
Thomas, Jennifer
Sempere, Lorenzo F.
Shapiro, Erik M.
NANOSCALE, 2020, 12 (14) : 7720 - 7734
[8] Contrast agents for x-ray luminescence computed tomography
Lun, Michael C.
Ranasinghe, Meenakshi
Arifuzzaman, Mohammad
Fang, Yile
Guo, Yiping
Anker, Jeffrey N.
Li, Changqing
APPLIED OPTICS, 2021, 60 (23) : 6769 - 6775
[9] Lead Oxide Nanoparticles as X-ray Contrast Agents for In Vitro and In Vivo Imaging
Al Saidi, Abdullah Khamis Ali
Baek, Ahrum
Liu, Shuwen
Mengesha, Tirusew Tegafaw
Ahmad, Mohammad Yaseen
Zhao, Dejun
Liu, Ying
Yang, Ji-ung
Park, Ji Ae
Hwang, Dong Wook
Chae, Kwon Seok
Nam, Sung-Wook
Chang, Yongmin
Lee, Gang Ho
ACS APPLIED NANO MATERIALS, 2023, 6 (21) : 20129 - 20138
[10] Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging
Kim, Dongkyu
Park, Sangjin
Lee, Jae Hyuk
Jeong, Yong Yeon
Jon, Sangyong
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (24) : 7661 - 7665

← 1 2 3 4 5 →