Synthesis and Biological Evaluation of New 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine Derivatives

被引：2
|
作者：
Prezent, Mikhail A. [1 ]
Baranin, Sergey, V [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prospect, Moscow 119991, Russia
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 44期
关键词：
antioxidants; heterocycles; 4; 5; 6; 7-tetrahydro-1H-imidazo[4; 5-c]pyridines; Suzuki reaction; radical-scavenging activity; ANTIOXIDANT; INHIBITORS; KINASE;
D O I：
10.1002/slct.202003440
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A number of new spinaceamine derivatives have been synthesized by the Suzuki reaction of 5-Boc-2-iodo-spinaciamine with aryl or heteryl boronic acids. The obtained compounds exhibited a varying degree of ABTS radical-scavenging activity, and some of them found to be more effective radical-scavengers comparing with spinacine. Both spinacine and its synthesized derivatives do not inhibit cholinesterases and carboxylesterase.
引用
收藏
页码：14017 / 14020
页数：4
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