This study investigates in a nonclinical sample some aspects of the reliability and validity of the Spanish adaptation of the Brief Symptom Inventory (BSI) as well as the relationship of personality dimensions and psychopathological symptoms. Factor analysis showed a six-factor structure: depression, phobic anxiety, paranoid ideation, obsession-compulsion, somatization, and hostility/aggressivity. Alpha reliabilities for the six BSI scales showed,optimal indices (between 0.70 and 0.91). Furthermore, the relationships among BSI-extracted factors and extraversion (E), neuroticism (N), and psychoticism (P) scales of the EPQ-R were also studied. Phobic anxiety and somatization were related to N and P; hostility/aggressivity was related to N, P and E; obsession-compuision was related to N, P and inversely to E. In conclusion, the Spanish version of the BSI is a reliable, valid, and rapid tool for the assessment of symptoms of depression, phobic anxiety, paranoid ideation, obsession-compulsion, somatization, and hostility/aggressivity in the nonclinical population.