Background, Current assessment of regional left ventricular function with electrocardiogram (EGG)-gated single photon emission computed tomography (SPECT) imaging is generally performed by visual inspection. The objective of this study was to develop and validate a new computer algorithm for quantifying regional left ventricular wall thickening on ECG-gated SPECT images. Methods. Regional wall thickening was measured from count density changes during the cardiac cycle observed in 24-sector circumferential count distribution profiles generated from each of 8 frames of an EGG-gated SPECT study. Wall thickening was expressed as the percent count increase during systole relative to end diastole. The program was tested in a phantom simulation and in patient studies consisting of a pilot study (n = 40) and a validation study (n = 33). In the phantom study varying degrees of wall thickening were simulated. The pilot study included 20 normal subjects with low likelihood (<3%) of coronary disease and 20 patients with prior myocardial infarction, Mean wall thickening -2 standard deviations, measured in normal subjects, defined the lower limit of normal wall thickening. This criterion was tested in the validation study in 13 normal subjects and 20 patients,vith prior myocardial infarction, Abnormal wall thickening was characterized by extent (percent of circumferential profile) and severity (minimal thickening). Results. The phantom study showed excellent linear correlation between wall thickening computed by the new software and actual wall thickening (r = 0.98), Interobserver and intraobserver reproducibility of quantitative assessment of minimal wall thickening were excellent (r = 0.98 and 0.99, P < .001). Regional wall thickening varied considerably from apex to base in the same ventricle among normal subjects. The average lower limit of normal wall thickening was 25% to 30% at the apex, 19% to 24% in the mid-ventricle, and 13% to 20% at the base of the left ventricle, In the validation study 11 of 13 normal subjects had wall thickening profiles within the predefined normal range, All 20 patients with prior myocardial infarction had abnormal regional wall thickening. Minimal regional wall thickening in the infarct areas was 5.4% +/- 5.5%, compared with 30.1% +/- 9.1% wall thickening in comparable anatomic areas in normal subjects (P < .001), Conclusion. Regional wall thickening can be quantified reliably from regional count density changes during the cardiac cycle on EGG-gated SPECT images, The new software measured the extent and severity of abnormal regional wall thickening relative to normal files. The method is highly reproducible. Clinical validation showed good differentiation between normal subjects and patients with prior infarction, Quantification of regional wall thickening may enhance diagnostic accuracy and reproducibility of interpretation of gated SPECT imaging.
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Michael Y. H. Shen
Yi-Hwa Liu
论文数: 0引用数: 0
h-index: 0
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Yi-Hwa Liu
Albert J. Sinusas
论文数: 0引用数: 0
h-index: 0
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Albert J. Sinusas
Robert Fetterman
论文数: 0引用数: 0
h-index: 0
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Robert Fetterman
Wendy Bruni
论文数: 0引用数: 0
h-index: 0
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Wendy Bruni
Oleg E. Drozhinin
论文数: 0引用数: 0
h-index: 0
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Oleg E. Drozhinin
Barry L. Zaret
论文数: 0引用数: 0
h-index: 0
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Barry L. Zaret
Frans J. Th. Wackers
论文数: 0引用数: 0
h-index: 0
机构:Yale University School of Medicine,Cardiovascular Nuclear Imaging and Exercise Laboratories, Departments of Internal Medicine (Cardiovascular Medicine) and Diagnostic Radiology (Nuclear Medicine)
Frans J. Th. Wackers
Journal of Nuclear Cardiology,
1999,
6
: 583
-
595
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Prasad, Mithun
Ramesh, Amit
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Ramesh, Amit
Kavanagh, Paul
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Kavanagh, Paul
Tamarappoo, Balaji K.
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Tamarappoo, Balaji K.
Nakazato, Ryo
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Nakazato, Ryo
Gerlach, James
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Gerlach, James
Cheng, Victor
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cheng, Victor
Thomson, Louise E. J.
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, AIM Program, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Thomson, Louise E. J.
Berman, Daniel S.
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Berman, Daniel S.
Germano, Guido
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Germano, Guido
Slomka, Piotr J.
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USACedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
机构:
Seoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South Korea
Paeng, JC
Lee, DS
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South Korea
Lee, DS
Cheon, GJ
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South Korea
Cheon, GJ
Lee, MM
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South Korea
Lee, MM
Chung, JK
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South Korea
Chung, JK
Lee, MC
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Med Nucl & Internal Med, Seoul, South Korea
机构:
North Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, Manhasset, NY USA
North Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, New Hyde Pk, NY USANorth Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, Manhasset, NY USA
Nichols, Kenneth
Van Tosh, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
St Francis Hosp, Res Dept, Roslyn, NY USANorth Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, Manhasset, NY USA
Van Tosh, Andrew
Wang, Yi
论文数: 0引用数: 0
h-index: 0
机构:
St Francis Hosp, Res Dept, Roslyn, NY USANorth Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, Manhasset, NY USA
Wang, Yi
Palestro, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, Manhasset, NY USA
North Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, New Hyde Pk, NY USANorth Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, Manhasset, NY USA
Palestro, Christopher
Reichek, Nathaniel
论文数: 0引用数: 0
h-index: 0
机构:
St Francis Hosp, Res Dept, Roslyn, NY USANorth Shore Long Isl Jewish Hlth Syst, Nucl Med & Mol Imaging, Manhasset, NY USA