Transition-metal-free access to 7-azaindoles

被引：10
|
作者：
Wang, Dong [1 ]
Hu, Jianyong [1 ]
Zhao, Junjie [1 ]
Shen, Meng [1 ]
Wang, Yuxi [1 ]
Yu, Peng [1 ]
机构：
[1] Tianjin Univ Sci & Technol, Coll Biotechnol, China Int Sci & Technol Cooperat Base Food Nutr S, Tianjin 300457, Peoples R China
来源：
TETRAHEDRON | 2018年 / 74卷 / 30期
关键词：
7-Azaindoles; Pyridine N-oxides; N-heterocycles; PALLADIUM-CATALYZED HETEROANNULATION; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; INTERNAL ALKYNES; N-OXIDES; C-H; ARYLATION; INHIBITORS; FUNCTIONALIZATION; AMINOPYRIDINES;
D O I：
10.1016/j.tet.2018.06.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method for transition-metal-free synthesis of 7-azaindoles is developed through a one-pot synthesis involving amination of pyridine N-oxides and intramolecular enamine formation. Remarkable features of the method include simple operation, mild reaction conditions, wide substrate scope, and easily accessible starting materials. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4100 / 4110
页数：11
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