Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis

被引：55
|
作者：
Chandrasekar, PH [1 ]
Cutright, JL [1 ]
Manavathu, EK [1 ]
机构：
[1] Wayne State Univ, Sch Med, Dept Internal Med, Div Infect Dis, Detroit, MI 48201 USA
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 10期
关键词：
amphotericin B; aspergillosis; guinea-pig model; micafungin; pulmonary aspergillosis; voriconazole;
D O I：
10.1111/j.1469-0691.2004.00958.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The efficacy of voriconazole in combination with amphotericin B or micafungin was studied in a transiently neutropenic guinea-pig model of invasive pulmonary aspergillosis. Guinea-pigs treated with the antifungal drugs, alone or in two-drug combinations, had an improved survival rate and reduced fungal burden in the lungs compared to untreated control animals. The efficacy of monotherapy and combination therapy was similar; activity was neither enhanced nor reduced with the two-drug combinations. Further studies of efficacy, dosing and optimal regimens for antifungal combinations are warranted.
引用
收藏
页码：925 / 928
页数：5
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