Contrasting population genetics of co-endemic cattle- and buffalo- derived Theileria annulata

被引：7

作者：

Chaudhry, Umer ^{[1
,5
]}

Ali, Qasim ^{[2
]}

Zheng, Lynn ^{[1
]}

Rashid, Imran ^{[3
]}

Shabbir, Muhammad Zubair ^{[3
]}

Numan, Muhammad ^{[4
]}

Ashraf, Kamran ^{[2
]}

Evans, Mike ^{[1
]}

Rafiq, Shahzad ^{[3
]}

Oneeb, Muhammad ^{[3
]}

Morrison, Liam J. ^{[1
]}

Morrison, W. Ivan ^{[1
]}

Sargison, Neil D. ^{[1
]}

机构：

[1] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin Inst, Edinburgh, Midlothian, Scotland

[2] Gomal Univ, Dept Parasitol, Dera Ismail Khan, Khyber Pakhtunk, Pakistan

[3] Univ Vet & Anim Sci, Dept Parasitol, Lahore, Pakistan

[4] Livestock & Dairy Dept, Dis Diagnost Lab, Okara, Pakistan

[5] Univ Surrey, Sch Vet Med, Dept Vet Epidemiol & Publ Hlth, Guildford GU2 7AL, Surrey, England

来源：

TICKS AND TICK-BORNE DISEASES | 2021年 / 12卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Theileria annulata; Tropical theileriosis; Vaccine cross-protection; Multiplicity of infection; Antiprotozoal drugs; SOFTWARE; PARVA; POLYMORPHISM; DIVERSITY; ANTIGEN;

D O I：

10.1016/j.ttbdis.2020.101595

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A study was designed to improve understanding of the genetics of Theileria annulata populations in sympatric cattle and Asian buffalo (Bubalus bubalus). The study was undertaken in the Punjab province of Pakistan, where the prevalence of tropical theileriosis is high. Parasite materials were collected from infected animals in defined regions, where cattle and Asian buffalo are kept together. Six satellite DNA markers and a mitochondrial cytochrome b marker were used to explore the multiplicity of T. annulata infection and patterns of emergence and spread of different parasite genotypes. The results show differences in the numbers of unique satellite locus alleles, suggesting that T. annulata is genetically more diverse in cattlethan in buffalo-derived populations. Heterozygosity (H-e) indices based on satellite and cytochrome b loci data show high levels of genetic diversity among the cattleand buffalo-derived T. annulata populations. When considered in the context of high parasite transmission rates and frequent animal movements between different regions, the predominance of multiple T. annulata genotypes and multiple introductions of infection may have practical implications for the spread of parasite genetic adaptations; such as those conferring vaccine cross-protection against different strains affecting cattle and Asian buffalo, or resistance to antiprotozoal drugs.

引用

页数：12

共 1 条

[1] Simultaneous Detection of Cattle-, Buffalo- and Yak-Derived Components by Triplex Quantitative Real-time Polymerase Chain Reaction
Wu S.
Zhang M.
Fang Y.
Chen Z.
Zhang Q.
Sun C.
Shen X.
Yu H.
Yin W.
Zhang X.
Shipin Kexue/Food Science, 2021, 42 (20): : 280 - 285

← 1 →