Effect of an intensive lifestyle intervention on the prevalence of metabolic syndrome and its components among overweight and obese adults

被引:7
|
作者
Guzman, M. [1 ]
Zbella, E. [2 ]
Alvarez, S. Shah [3 ]
Nguyen, J. L. [4 ]
Imperial, E. [5 ]
Troncale, F. J. [6 ]
Holub, C. [7 ]
Mallhi, A. K. [1 ]
VanWyk, S. [8 ]
机构
[1] Medi Weightloss, Div Res & Dev, Dept Med Affairs, 509 South Hyde Pk Ave, Tampa, FL 33606 USA
[2] Florida Fertil Inst, 2454 N McMullen Booth Rd Suite 601, Clearwater, FL 33759 USA
[3] Medi Weightloss, Dept Med Affairs, 509 South Hyde Pk Ave, Tampa, FL 33606 USA
[4] Mercer Univ, Coll Pharm, Dept Pharm Practice, 3001 Mercer Univ Dr, Atlanta, GA 30341 USA
[5] Iredell Primary Care Women, 114 Gateway Blvd,Suite B, Mooresville, NC 28117 USA
[6] Yale Univ, Sect Gastroenterol, Sch Med, 333 Cedar St, New Haven, CT 06510 USA
[7] Calif State Univ, Coll Educ Hlth & Human Serv, Dept Publ Hlth, 333 S Twin Oaks Valley Rd, San Marcos, CA 92096 USA
[8] 2518 69th Ave S, St Petersburg, FL 33712 USA
关键词
obesity; chronic disease; WEIGHT-LOSS; RISK; LIPOPROTEIN; MANAGEMENT;
D O I
10.1093/pubmed/fdz170
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Despite the fact that up to a third of the global population has metabolic syndrome (MetS), it has been overlooked in clinical settings. This study assesses the impact of a physician-supervised nonsurgical weight management program on the prevalence of MetS and its key indicators. Methods Four-hundred seventy-nine overweight and obese participants aged 19 years or older were included in a prospective longitudinal study. Changes in MetS and its key indicators were assessed using the binomial exact, chi-square and Wilcoxon signed-rank tests in an intent-to-treat study population. Differences in age strata were assessed using a generalized linear model. Results Fifty-two percent of participants (n = 249) had MetS at baseline. Prevalence of MetS decreased steadily with significant changes from baseline observed at weeks 13 (31.8%, P < 0.0001), 26 (28.7%, P < 0.0012) and 39 (21.6%, P < 0.0002); changes from baseline were observed at week 52 as statistically significant (16.7%, P < 0.0012). Improvements in anthropometrics and levels of key indicators of MetS were observed throughout the study. Conclusion These findings confirm that weight loss is inversely associated with prevalence of MetS and its key indicators among overweight and obese individuals. Future studies may benefit from a larger sample size and better retention.
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页码:828 / 838
页数:11
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