Effect of gefitinib on brain metastases from non-small cell lung cancer - Two case reports

被引：7
|
作者：
Nishi, Noriyuki [1 ]
Kawai, Shozo [1 ]
Yonezawa, Taiji [1 ]
Fujimoto, Kenta [1 ]
Masui, Katsuya [1 ]
机构：
[1] Osaka Gen Med Ctr, Dept Neurosurg, Sumiyoshi Ku, Osaka 5588558, Japan
来源：
NEUROLOGIA MEDICO-CHIRURGICA | 2006年 / 46卷 / 10期
关键词：
gefitinib; brain metastasis; non-small cell lung cancer; epidermal growth factor receptor; molecular-target therapy;
D O I：
10.2176/nmc.46.504
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Two patients with non-small cell lung cancer presented with multiple brain metastases. They received gefitinib orally for the treatment of the primary lung lesions. About one month later, the brain metastases unexpectedly disappeared or became smaller. The patients survived without recurrence of brain metastases and growth of lung lesions for 3-4 years. Gefitinib is a selective epidermal growth factor receptor tyrosine kinase inhibitor and is approved for use in the treatment of non-small cell lung cancer. Gefitinib may be very effective for multiple brain metastases in patients with non-small cell lung cancer.
引用
收藏
页码：504 / 507
页数：4
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