An investigation of template anchoring strategy for molecularly imprinting materials based on nanomagnetic polyhedral oligomeric silsesquioxanes composites

A template anchoring strategy for high performance molecularly imprinting materials (MI-materials) was displayed in the present work, which involved efficient usage of template molecules with the aid of functional monomer grafted on the support. The imprinting polymerization process was carried out on the surface of carboxyl functionalized Fe3O4@POSS (Fe3O4@POSS-COON) anchoring with tetracycline templates as a demonstration. In this strategy, Fe3O4@POSS-COOH was first prepared via a simple copolymerization between methacrylic acid (MAA) and the residual end vinyl groups of Fe3O4@POSS. The carboxyl groups immobilized on Fe3O4@POSS surface can drive tetracycline templates into the formed polymer layers through hydrogen interactions between tetracycline and the functionalized monomer. The occupation of assembled tetracycline templates on the surface of Fe3O4@POSS-COOH directed the selective occurrence of imprinting polymerization through copolymerization of vinyl end groups of Fe3O4@POSS, leading to the formation of tetracycline imprinted nanocomposite with a high density of effective recognition sites. The obtained MI-material exhibited high capacity and favorable selectivity towards tetracycline antibiotics. By applying the proposed MI-material as magnetic solid phase extraction adsorbents, four tetracyclines were prominently enriched from milk samples. The MI-material based analytical platform was sensitive for the determination of TCs in milk samples with LOD values in the range of 2.23-26.84 ng mL(-1) and recoveries ranged from 86.2% to 105.7%. This work proposed an improved strategy for preparing efficient MI-materials based on Fe3O4@POSS, which provides a new insight into the chemical properties of Fe3O4@POSS. (C) 2019 Elsevier B.V. All rights reserved.