H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation

被引：53
|
作者：
Sluss, Hayla K. [1 ]
Davis, Roger J.
机构：
[1] Univ Massachusetts, Sch Med, Dept Canc Cell Biol, Worcester, MA 01605 USA
[2] Univ Massachusetts, Sch Med, Mol Sci Program, Worcester, MA 01605 USA
[3] Howard Hughes Med Inst, Worcester, MA 01605 USA
来源：
MOLECULAR CELL | 2006年 / 23卷 / 02期
关键词：
D O I：
10.1016/j.molcel.2006.07.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanism of apoptotic signaling by JNK is incompletely understood. In the July 7 issue of Molecular Cell, Lu et al. (2006) report that JNK phosphorylation of H2AX at a noncanonical site is required for caspase-induced DNA fragmentation.
引用
收藏
页码：152 / 153
页数：2
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