In vitro activity of Bay 12-8039, a new 8-methoxyquinolone, compared to the activities of 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans

The in vitro activity of Bay 12-8039, a new oral 8-methoxyquinolone, was compared to the activities of 11 other oral antimicrobial agents (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, azithromycin, clarithromycin, amoxicillin clavulanate, penicillin, cefuroxime, cefpodoxime, and doxycycline) against 250 aerobic and 140 anaerobic bacteria recently isolated from animal and human bite wound infections, Bay 12-8039 was active against all aerobic isolates, both gram-positive and gram-negative isolates, at less than or equal to 1.0 mu g/ml (MICs at which 90% of isolates are inhibited [MIC90s less than or equal to 0.25 mu g/ml) and was active against most anaerobes at less than or equal to 0.5 mu g/ml; the exceptions were Fusobacterium nucleatum and other Fusobacterium species (MIC(90)s, greater than or equal to 4.0 mu g/ml) and one strain of Prevotella loeschii (MICs, 2.0 mu g/ml). In comparison, the other quinolones tested had similar in vitro activities against the aerobic strains but were less active against the anaerobes, including peptostreptococci, Porphyromonas species, and Prevotella species. The fusobacteria were relatively resistant to all the antimicrobial agents tested except penicillin G (one penicillinase-producing strain off. nucleatum was found) and amoxicillin clavulanate.