New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity

被引：7
|
作者：
Xiong, Yan [1 ,2 ,3 ,5 ]
Yi, Ping [1 ,2 ,3 ]
Li, Yuhuan [4 ]
Gao, Rongmei [4 ]
Chen, Junlei [1 ,2 ,3 ]
Hu, Zhanxing [1 ,2 ,3 ]
Lou, Huayong [1 ,2 ,3 ]
Du, Caixia [1 ,2 ,3 ]
Zhang, Jiayu [1 ,2 ,3 ]
Zhang, Yu [6 ]
Yuan, Chunmao [1 ,2 ,3 ]
Huang, Liejun [1 ,2 ,3 ]
Hao, Xiaojiang [1 ,2 ,3 ,6 ]
Gu, Wei [1 ,2 ,3 ]
机构：
[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China
[2] Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China
[3] Chinese Acad Sci, Guiyang, Peoples R China
[4] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
[5] Guizhou Nursing Vocat Coll, Guiyang, Peoples R China
[6] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Blumea balsamifera (L; ) DC; Asteraceae; sesquiterpeniod esters; anti-influenza virus activity; EXTRACTS; FLAVONOIDS;
D O I：
10.1080/14786419.2020.1861615
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Phytochemical studies led to the isolation of five new sesquiterpeniod esters, named balsamiferine N-R, along with ten known compounds (6-15) from the leaves of Blumea balsamifera (L.) DC. The skeletons of nine known sesquiterpeniods belong to guaiane and eudesmane. The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, and quantum-chemical electronic circular dichroism (ECD) calculation. Compounds 3 and 4 showed significant inhibitory effects on influenza A virus (H3N2) with IC50 values of 46.23 mu g/mL and 38.49 mu g/mL, respectively. It was the first report on the anti-influenza A virus constituents from B. balsamifera.
引用
收藏
页码：1151 / 1160
页数：10
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