Complete Responses in Relapsed/Refractory Acute Myeloid Leukemia (AML) Patients on a Weekly Dosing Schedule of Vibecotamab (XmAb14045), a CD123 x CD3 T Cell-Engaging Bispecific Antibody; Initial Results of a Phase 1 Study

被引:48
|
作者
Ravandi, Farhad
Bashey, Asad
Stock, Wendy
Foran, James M.
Mawad, Raya
Egan, Daniel
Blum, William
Yang, Allen
Pastore, Alessandro
Johnson, Chelsea
Zheng, Shuo
Yilmaz, Musa
Mims, Alice S.
机构
关键词
D O I
10.1182/blood-2020-134746
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [1] Complete Responses in Relapsed/Refractory Acute Myeloid Leukemia (AML) Patients on a Weekly Dosing Schedule of XmAb14045, a CD123 x CD3 T Cell-Engaging Bispecific Antibody: Initial Results of a Phase 1 Study
    Ravandi, Farhad
    Bashey, Asad
    Foran, James M.
    Stock, Wendy
    Mawad, Raya
    Blum, William
    Saville, M. Wayne
    Johnson, Chelsea M.
    Vanasse, K. Gary J.
    Ly, Thomas
    Kantarjian, Hagop M.
    Bhatnagar, Bhavana
    Takahashi, Koichi
    Mims, Alice S.
    BLOOD, 2018, 132
  • [2] Preliminary Results of a Phase 1 Study of Flotetuzumab, a CD123 x CD3 Bispecific Dart® Protein, in Patients with Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome
    Uy, Geoffrey L.
    Godwin, John
    Rettig, Michael P.
    Vey, Norbert
    Foster, Matthew
    Arellano, Martha L.
    Rizzieri, David A.
    Topp, Max S.
    Huls, Gerwin
    Lowenberg, Bob
    Martinelli, Giovanni
    Paolini, Stefania
    Ciceri, Fabio
    Carrabba, Matteo Giovanni
    Ballesteros-Merino, Carmen
    Bifulco, Carlo B.
    Lelievre, Helene
    La Motte-Mohs, Ross
    Li, Daner
    Sun, Jichao
    Jacobs, Kenneth
    Spohn, Karen
    Lonsdale, Nadia
    Tran, Kathy
    Baughman, Jan
    Shannon, Michele
    Fox, Bernard
    Bonvini, Ezio
    Wigginton, Jon
    Davidson-Moncada, Jan
    DiPersio, John F.
    BLOOD, 2017, 130
  • [3] Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein, in Salvage Therapy for Primary Refractory and Early Relapsed Acute Myeloid Leukemia (AML) Patients
    Uy, Geoffrey L.
    Aldoss, Ibrahim
    Foster, Matthew C.
    Sallman, David A.
    Sweet, Kendra L.
    Rizzieri, David A.
    Sayre, Peter H.
    Advani, Anjali S.
    Emadi, Ashkan
    Wieduwilt, Matthew J.
    Vey, Norbert
    Ciceri, Fabio
    Carrabba, Matteo Giovanni
    Moyo, Tamara
    Church, Sarah E.
    Rettig, Michael P.
    Arellano, Martha L.
    Godwin, John E.
    Lowenberg, Bob
    Huls, Gerwin
    Ravandi, Farhad
    Muth, John
    Tran, Kathy
    Jongen-Lavrencic, Mojca
    Timmeny, Erin
    Topp, Max S.
    Paolini, Stefania
    Guo, Kuo
    Curtis, Teia
    Zhao, Jian
    Vadakekolathu, Jayakumar
    Wigginton, Jon M.
    Bonvini, Ezio
    Rutella, Sergio
    Walter, Roland B.
    Davidson-Moncada, Jan K.
    DiPersio, John F.
    BLOOD, 2019, 134
  • [4] Adaptive Immune Gene Signatures Correlate with Response to Flotetuzumab, a CD123 X CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia
    Rutella, Sergio
    Church, Sarah E.
    Vadakekolathu, Jayakumar
    Viboch, Elena
    Sullivan, Amy H.
    Hood, Tressa
    Warren, Sarah E.
    Cesano, Alessandra
    La Motte-Mohs, Ross
    Muth, John
    Lelievre, Helene
    Lowenberg, Bob
    DiPersio, John F.
    Davidson-Moncada, Jan K.
    BLOOD, 2018, 132
  • [5] First-in-human study of JNJ-63709178, a CD123/CD3 targeting antibody, in relapsed/refractory acute myeloid leukemia
    Boyiadzis, Michael
    Desai, Pinkal
    Daskalakis, Nikki
    Donnellan, William
    Ferrante, Lucille
    Goldberg, Jenna D.
    Grunwald, Michael R.
    Guttke, Christina
    Li, Xiang
    Perez-Simon, Jose Antonio
    Salamero, Olga
    Tucker, Trevor
    Xu, Xiaoying
    Yang, Jay
    Pemmaraju, Naveen
    Alonso-Dominguez, Juan Manuel
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2023, 16 (03): : 429 - 435
  • [6] Dose Escalation of HLA-A2-WT1 CD3 T-Cell Bispecific Antibody in a Phase I Study in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)
    Hutchings, Martin
    Montesinos, Pau
    Santoro, Armando
    Hou, Hsin-An
    Martinez-Sanchez, Maria Pilar
    Vives, Susana
    Galimberti, Sara
    Chen, Tsai-Yun
    Frigeni, Marco
    Garciaz, Sylvain
    Salamero, Olga
    Yeh, Su-Peng
    Yee, Karen
    Schnetzler, Gabriel
    Barata, Teresa
    Simon, Silke
    Hinton, Heather
    Korfi, Koorosh
    Richard, Muriel
    Keshelava, Nino
    Subklewe, Marion
    BLOOD, 2023, 142
  • [7] A Phase 1 Study of XmAb18968, a CD3-CD38 Bispecific Antibody for the Treatment of Patients with Relapsed/Refractory Acute Leukemia and T Cell Lymphoblastic Lymphoma
    Murthy, Guru Subramanian Guru
    Kearl, Tyce J.
    Cui, Weiguo
    Johnson, Bryon
    Hoffmeister, Karin
    Szabo, Aniko
    Aoki, Kazuhiro
    Harrington, Alexandra M.
    Carlson, Karen
    Michaelis, Laura C.
    Runaas, Lyndsey
    Abedin, Sameem
    Duvall, Adam S.
    Stock, Wendy
    Shah, Bijal D.
    Leonard, Jessica
    Pratz, Keith W.
    Luger, Selina M.
    Badar, Talha
    Baim, Arielle
    Yaghoubi, Shahriar
    Atallah, Ehab L.
    BLOOD, 2021, 138
  • [8] A Phase 1 Study of Flotetuzumab, a CD123 x CD3 DART® Protein, Combined with MGA012, an Anti-PD-1 Antibody, in Patients with Relapsed or Refractory Acute Myeloid Leukemia
    Wei, Andrew H.
    Fong, Chun Yew
    Montesinos, Pau
    Calbacho, Maria
    Gil, Jordi Sierra
    Perez De Oteyza, Jaime
    Rowe, Jacob M.
    Wolach, Ofir
    Ofran, Yishai
    Moshe, Yakir
    Sun, Jichao
    Baughman, Jan
    McNulty, Eileen
    Bonvini, Ezio
    Wigginton, Jon M.
    Davidson-Moncada, Jan K.
    BLOOD, 2019, 134
  • [9] A Phase 1 Study of CD38-Bispecific Antibody (XmAb18968) for Patients with CD38 Expressing Relapsed/Refractory Acute Myeloid Leukemia
    Murthy, Guru Subramanian Guru
    Leonard, Jessica T.
    Badar, Talha
    Yi, Cecilia Y. Arana
    Duvall, Adam S.
    Shah, Bijal D.
    Baim, Arielle
    Kearl, Tyce
    Harrington, Alexandra M.
    Szabo, Aniko
    Atallah, Ehab L.
    BLOOD, 2023, 142
  • [10] A Phase 1 Study of CD38-Bispecific Antibody (XmAb18968) for Patients with Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia
    Murthy, Guru Subramanian Guru
    Shah, Bijal D.
    Duvall, Adam S.
    Leonard, Jessica T.
    Badar, Talha
    Yi, Cecilia Y. Arana
    Kearl, Tyce
    Baim, Arielle
    Harrington, Alexandra M.
    Szabo, Aniko
    Atallah, Ehab L.
    BLOOD, 2023, 142