Synthesis of novel L-series 2',3'-dideoxy-3'-hydroxymethylnucleosides and a convenient method for the separation of nucleoside anomers

被引：3
|
作者：
Gould, JHM
Mann, J
机构：
[1] Department of Chemistry, Reading University, Whiteknights
来源：
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 1-2期
基金：
英国工程与自然科学研究理事会; 英国医学研究理事会;
关键词：
D O I：
10.1080/07328319708002533
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Photoinduced addition of methanol to S(R)-(tert-butyldimethylsilyloxymethyl)-2(5H)-furan-2-one (derived from L-gulono-1,4-lactone) provided the photoadduct 5 (R)-(tert-butyldimethylsiloxymethyl)-4(S)-hydroxymethyl-tetrahydrofuran-2-one, which was converted into two L-series-2',3'-dideoxy-3'-hydroxymethyl-nucleosides. In addition, we describe a new method for the chromatographic separation of cytidine anomers using a N-2-(4-nitrophenyl)ethyl carbamate derivative.
引用
收藏
页码：193 / 213
页数：21
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