Synthesis and evaluation of transition-state analogue inhibitors of α-1,3-fucosyltransferase

被引：0
|
作者：
Mitchell, ML
Tian, F
Lee, LV
Wong, CH
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 16期
关键词：
D O I：
10.1002/1521-3773(20020816)41:16<3041::AID-ANIE3041>3.0.CO;2-V
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mimics of the geometry or charge of the fucose moiety of GDP-fucose in the transition state of fucosyltransferase-catalyzed reactions, compounds 1-3 are good competive inhibitors of α-1,3-fucosyltransferases V and VI with Ki values between 6 and 13 μM. GDP = guanosine diphosphate.
引用
收藏
页码：3041 / 3044
页数：4
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