Topoisomerases interlink genetic network underlying autism

被引：4
|
作者：
Vokalova, Lenka [1 ]
Durdiakova, Jaroslava [1 ]
Ostatnikova, Daniela [1 ]
机构：
[1] Comenius Univ, Fac Med, Inst Physiol, Bratislava 81372, Slovakia
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2015年 / 47卷
关键词：
Topoisomerase; Neurodevelopment; ASD; AXON-GUIDANCE RECEPTORS; CENTRAL-NERVOUS-SYSTEM; CAJAL-RETZIUS CELLS; II-BETA; BRAIN-DEVELOPMENT; DNA; REELIN; TRANSCRIPTION; INVOLVEMENT; EXPRESSION;
D O I：
10.1016/j.ijdevneu.2015.07.009
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
DNA topoisomerases belong to the group of proteins that play an important role in the organizational dynamics of the human genome. Their enzymatic activity solves topological strain rising from DNA supercoiling occurring during transcription. DNA topoisomerases are especially important for transcription of genes involved in neurodevelopment. Disruption of topoisomerase activity in animal models resulted in impaired neurodevelopment and changed brain architecture. Recent research revealed that topoisomerases induced expression of the same group of genes as those associated with autism. Transcriptional inhibition of neuronal genes during critical stages of brain development may be responsible for pathology of neurodevelopmental disorders such as autism. In this review we aim to outline the role of topoisomerase in neurodevelopment and its possible linkage to neuropathology of autism. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：361 / 368
页数：8
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