Microvascular disorders induced by malaria infected red blood cells: a computational mechanical study using the biological particle method

被引：0
|
作者：
Yamaguchi, T. [1 ]
Kondo, H. [2 ]
Imai, Y. [2 ]
Ishikawa, T. [2 ]
机构：
[1] Tohoku Univ, Dept Biomed Engn, Grad Sch Biomed Engn, Sendai, Miyagi 980, Japan
[2] Tohoku Univ, Grad Sch Engn, Dept Bioengn & Robot, Sendai, Miyagi, Japan
来源：
MODELLING IN MEDICINE AND BIOLOGY VIII | 2009年 / 13卷
关键词：
malaria; computational fluid dynamics; particle method; red blood cell; microcirculation; mechanical properties of cell membrane; SINGLE-CELL;
D O I：
10.2495/BIO090051
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We simulated malarial microvascular blood flow disturbances by using a new particle method of biological solid-fluid interaction analysis especially developed for the analysis of malaria infection. Particle based spatial discretization and the sub time step time integration could provide us with stable computations for micro scale blood flow involving interaction with many cells. We performed numerical simulation of the stretching of infected red blood cells and the results agreed well with experimental results. Our model successfully simulated the flow of infected red blood cells into narrow channels.
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页码：49 / +
页数：2
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