Interplay between Glass Formation and Liquid-Liquid Phase Separation Revealed by the Scattering Invariant

被引：19

作者：

Da Vela, Stefano ^{[1
]}

Begam, Nafisa ^{[1
]}

Dyachok, Danylo ^{[1
]}

Schaeufele, Richard Santiago ^{[1
]}

Matsarskaia, Olga ^{[1
]}

Braun, Michal K. ^{[1
]}

Girelli, Anita ^{[1
]}

Ragulskaya, Anastasia ^{[1
]}

Mariani, Alessandro ^{[2
]}

Zhang, Fajun ^{[1
]}

Schreiber, Frank ^{[1
]}

机构：

[1] Univ Tubingen, Inst Angew Phys, D-72076 Tubingen, Germany

[2] European Synchrotron Radiat Facil, F-38043 Grenoble, France

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2020年 / 11卷 / 17期

关键词：

SPINODAL DECOMPOSITION; SMALL-ANGLE; BEHAVIOR; GELATION; MIXTURE; USAXS;

D O I：

10.1021/acs.jpclett.0c02110

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The interplay of the glass transition with liquid-liquid phase separation (LLPS) is a subject of intense debate. We use the scattering invariant Q to probe how approaching the glass transition affects the shape of LLPS boundaries in the temperature/volume fraction plane. Two protein systems featuring kinetic arrest with a lower and an upper critical solution temperature phase behavior, respectively, are studied varying the quench depth. Using Q we noninvasively identify system-dependent differences for the effect of glass formation on the LLPS boundary. The glassy dense phase appears to enter the coexistence region for the albumin-YCl3 system, whereas it follows the equilibrium binodal for the gamma-globulin-PEG system.

引用

页码：7273 / 7278

页数：6

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