Evaluating the Past and Present of Regenerative Medicine (RM)'' was the first part of an Industry Symposium dedicated to the subject during the 2015 TERMIS World Congress in Boston. This working session presented a critical review of the current RM landscape in Europe and North America with possible projections for the future. Interestingly, the RM development cycle seems to obey the Gartner hype cycle, now at the enlightenment phase, after past exaggerated expectations and discouragements, as suggested by increasing numbers of clinical trials and recent market approvals of RM solutions in both Europe (Glybera and Holoclar (R) from Chiesi Pharma and Strimvelis (R) from GSK) and Japan (Remestemcel-L from Mesoblast (R)). The successful commercial translation of RM research is governed by five major drivers: (i) fully validated manufacturing capability for autologous or allogeneic products, (ii) reimbursement for targeted clinical indications with high and demonstrable medico-economic benefits versus standard of care, (iii) implication of regulatory bodies in the design and development plan of any RM solution, which should be well characterized, robust, with proven consistent efficacy and an acceptable and controlled positive benefit/risk ratio, (iv) collaborations facilitated by multi-competence hubs/consortia of excellence, (v) well-thought-out clinical development plans for reducing the risk of failure. Benefiting from past and present experience, the RM burgeoning industry is expected to accelerate the market release of cost-effective RM products with real curative potential for specific clinical indications with high unmet needs. This should be achieved by wisely leveraging all possible synergies of the different stakeholders, for example, patients, clinicians, reimbursement and health technology assessment (HTA) agencies, regulatory authorities, public/private investors, academia, and companies. 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J Ronk, A; Szava-Kovats, R; Zobel, M; Pärtel, M Ronk, Argo; Szava-Kovats, Robert; Zobel, Martin; Partel, Meelis Observed and dark diversity of alien plant species in Europe: estimating future invasion risk BIODIVERSITY AND CONSERVATION English Article Community completeness; Exotic species; Human activity; Land-use; Non-native species; Relative richness BETA DIVERSITY; PATTERNS; BIODIVERSITY; CLIMATE; FLORA; ECOSYSTEMS; RICHNESS; POOLS Invasion by alien species is a growing concern for nature conservation. We estimated the level of invasion by alien plant species and future invasion risks at the European scale. We used a pan-European atlas and eight regional plant atlases to determine the distribution of alien and native plant richness. In addition, we estimated alien and native dark diversity (species currently absent from a site but present in the surrounding region and able to colonize the site). We used relative diversity metrics to indicate current and future risks by alien species: relative alien richness (compared to native species), alien and native completeness (log-ratio of observed to dark diversity) and completeness difference between alien and native species. Observed and relative richness of alien species were greatest in NW Europe; this suggests that sites in NW Europe could be more disturbed. Observed alien and native species richness show clear regional hotspots; the distribution of completeness values is dispersed, indicating local hotspots. Northern Europe has relatively lower alien completeness, likely because potential invaders inhabit the region but have not yet reached many localities, thereby suggesting a risk of future invasion. A greater number of potential alien species in the region increases the probability that some alien species could have detrimental impacts. Both alien richness and completeness are positively correlated with native richness and completeness, respectively, indicating that both groups share similar distribution patterns. Alien species diversity metrics in Europe are related positively to human population density and agricultural land-use. We suggest that the dark diversity concept can broaden our understanding of alien species diversity and future invasion risks. [Ronk, Argo; Szava-Kovats, Robert; Zobel, Martin; Partel, Meelis] Univ Tartu, Inst Ecol & Earth Sci, Lai 40, EE-51005 Tartu, Estonia University of Tartu; Tartu University Institute of Ecology & Earth Sciences Ronk, A (corresponding author), Univ Tartu, Inst Ecol & Earth Sci, Lai 40, EE-51005 Tartu, Estonia. argo.ronk@ut.ee Zobel, Martin/H-1336-2015; Pärtel, Meelis/D-5493-2012 Zobel, Martin/0000-0001-7957-6704; Pärtel, Meelis/0000-0002-5874-0138; Ronk, Argo/0000-0002-8716-976X; Szava-Kovats, Robert/0000-0001-7966-1327 Estonian Ministry of Education and Research, institutional research funding [IUT 20-28, 20-29]; European Union through the European Regional Development Fund (Centre of Excellence EcolChange) Estonian Ministry of Education and Research, institutional research funding; European Union through the European Regional Development Fund (Centre of Excellence EcolChange) This study was supported by the Estonian Ministry of Education and Research, institutional research funding (IUT 20-28, 20-29) and the European Union through the European Regional Development Fund (Centre of Excellence EcolChange). 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Conserv. APR 2017 26 4 899 916 10.1007/s10531-016-1278-4 http://dx.doi.org/10.1007/s10531-016-1278-4 18 Biodiversity Conservation; Ecology; Environmental Sciences Science Citation Index Expanded (SCI-EXPANDED) Biodiversity & Conservation; Environmental Sciences & Ecology EQ5GQ 2024-02-21 WOS:000398111000008
J Roriz, M; Lopes, A; Jarrin, I; Lechtman, S; Polivka, M; Bergmann, JF; Sène, D; Mouly, S Roriz, M.; Lopes, A.; Jarrin, I.; Lechtman, S.; Polivka, M.; Bergmann, J. -F.; Sene, D.; Mouly, S. Central nervous system lymphoma revealed by lymphocytic meningitis in a patient with systemic lupus erythematosus: An unusual association REVUE DE MEDECINE INTERNE French Article Lymphoma; Central nervous system; Systemic erythematosus lupus; Meningitis B-CELL LYMPHOMA; MYCOPHENOLATE-MOFETIL; INFLAMMATORY DISORDERS; AUTOIMMUNE; CNS; MALIGNANCY; DISEASE; RISK Introduction. - We report an unusual observation of central nervous system (CNS) lymphoma in a 60 year-old woman with systemic lupus erythematosus and fatal outcome. Observation. - The patient had systemic erythematosus lupus for 7 years, treated with mycophenolate mofetil and developed lymphocytic meningitis in 2015 associated to the presence of EBV in the cerebrospinal fluid and a necrotic vermis' lesion. Diagnosis of large B-cell lymphoma was histologically confirmed from stereotaxic biopsy, shortly before she died from neurological complications. Conclusion. - Even though the current association is unusual, lymphocytic meningitis with hypogly-corrachia in patients with systemic lupus erythematosus may reveal CNS lymphoma and diagnosis confirmation requires stereotaxic biopsy in order not to delay specific therapeutic management. (C) 2016 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved. [Roriz, M.; Lopes, A.; Jarrin, I.; Lechtman, S.; Bergmann, J. -F.; Sene, D.; Mouly, S.] Grp Hosp Lariboisiere, Hop Fernand Widal, AP HP, Dept Med Interne, 2 Rue Ambroise Pare, F-75475 Paris 10, France; [Polivka, M.] Hop Lariboisiere, AP HP, Serv Anatomopathol, 2 Rue Ambroise Pare, F-75010 Paris, France; [Roriz, M.; Lechtman, S.; Bergmann, J. -F.; Sene, D.; Mouly, S.] UFR Med Paris Diderot, UMR S1144, 10 Ave Verdun, F-75010 Paris, France Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse - APHP; Universite Paris Cite; Hopital Universitaire Hotel-Dieu - APHP; Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Hopital Universitaire Hotel-Dieu - APHP; Hopital Universitaire Paul-Brousse - APHP; Universite Paris Cite Roriz, M (corresponding author), Grp Hosp Lariboisiere, Hop Fernand Widal, AP HP, Dept Med Interne, 2 Rue Ambroise Pare, F-75475 Paris 10, France. melanie.roriz@aphp.fr sene, damien/R-3970-2017; Bergmann, Jean-Francois/L-6044-2017 sene, damien/0000-0001-8640-4580; Bergmann, Jean-Francois/0000-0001-6861-9748 Abrey LE, 2009, CURR OPIN NEUROL, V22, P675, DOI 10.1097/WCO.0b013e328332533b; AbuShakra M, 1996, ARTHRITIS RHEUM, V39, P1050, DOI 10.1002/art.1780390625; Apora E, 2014, LEUKEMIA RES, V38, P1067, DOI 10.1016/j.leukres.2014.06.025; Baecklund E, 2014, SEMIN CANCER BIOL, V24, P61, DOI 10.1016/j.semcancer.2013.12.001; Batchelor T, 2006, J CLIN ONCOL, V24, P1281, DOI 10.1200/JCO.2005.04.8819; Biasiotta A, 2010, NEUROL SCI, V31, P647, DOI 10.1007/s10072-010-0338-x; Cao LH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122964; Chamberlain MC, 2005, J NEURO-ONCOL, V75, P71, DOI 10.1007/s11060-004-8100-y; Cho S, 1999, AM J KIDNEY DIS, V34, P296; CRAS P, 1989, CLIN NEUROPATHOL, V8, P200; Dasgupta N, 2005, LUPUS, V14, P910, DOI 10.1191/0961203303lu2179cr; Di Noto R, 2008, LEUKEMIA RES, V32, P1196, DOI 10.1016/j.leukres.2007.12.016; Ferreri AJM, 2003, J CLIN ONCOL, V21, P266, DOI 10.1200/JCO.2003.09.139; Finelli PF, 2006, LUPUS, V15, P886, DOI 10.1177/0961203306071431; GUTMANN J, 1994, CLIN RADIOL, V49, P696, DOI 10.1016/S0009-9260(05)82663-7; Knight JS, 2014, LUPUS SCI MED, V1, DOI 10.1136/lupus-2014-000051; Lai GGY, 2011, ACTA ONCOL, V50, P144, DOI 10.3109/0284186X.2010.504231; LIPSMEYER EA, 1972, ARTHRITIS RHEUM-US, V15, P183, DOI 10.1002/art.1780150207; Matsuura T, 1987, Nihon Naika Gakkai Zasshi, V76, P730; Mellemkjaer L, 1997, ARTHRITIS RHEUM-US, V40, P761, DOI 10.1002/art.1780400424; MELLORS RC, 1965, J EXP MED, V122, P25, DOI 10.1084/jem.122.1.25; Pisoni CN, 2003, MEDICINA-BUENOS AIRE, V63, P221; Rasmussen NS, 2015, SCAND J RHEUMATOL, V44, P143, DOI 10.3109/03009742.2014.973061; Smedby KE, 2006, JNCI-J NATL CANCER I, V98, P51, DOI 10.1093/jnci/djj004; Sultan SM, 2000, RHEUMATOLOGY, V39, P1147, DOI 10.1093/rheumatology/39.10.1147; Suresh S, 2016, SURV OPHTHALMOL, V61, P357, DOI 10.1016/j.survophthal.2015.10.001; Svobodova B, 2011, LUPUS, V20, P1452, DOI 10.1177/0961203311412413; TOMABECHI M, 1992, Neurological Surgery, V20, P429; Tsang HHL, 2010, LUPUS, V19, P330, DOI 10.1177/0961203309347921; Tse TPK, 2014, HONG KONG MED J, V20, P541, DOI 10.12809/hkmj134095; Waldman MA, 2004, J AM ACAD DERMATOL, V51, pS124, DOI 10.1016/j.jaad.2004.03.020; WOOLF AS, 1987, POSTGRAD MED J, V63, P569, DOI 10.1136/pgmj.63.741.569; Zintzaras E, 2005, ARCH INTERN MED, V165, P2337, DOI 10.1001/archinte.165.20.2337 33 1 1 0 0 ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER ISSY-LES-MOULINEAUX 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE 0248-8663 REV MED INTERNE Rev. 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J Rosculet, N; Zhou, XC; Ha, P; Tang, M; Levine, MA; Neuner, G; Califano, J Rosculet, Nicholas; Zhou, Xian Chong; Ha, Patrick; Tang, Mei; Levine, Marshall A.; Neuner, Geoffrey; Califano, Joseph Neutrophil-to-lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK English Article neutrophil-to-lymphocyte ratio; human papillomavirus (HPV); head and neck squamous cell carcinoma; inflammatory markers; prognosis ORAL-CAVITY; NEUTROPHIL/LYMPHOCYTE; SURVIVAL; COUNT Background. The neutrophil-to-lymphocyte ratio (NLR) has prognostic significance for many cancers, with higher values correlating with poor outcomes. The purpose of this study was to determine the prognostic significance of this inflammatory marker for patients with head and neck squamous cell carcinoma (HNSCC). Methods. Univariate logistic regression and multivariate Cox regression analyses were performed on a retrospective cohort of 123 patients treated with primary chemoradiotherapy. Results. The NLR is an indicator of both recurrence-free and overall survival, but the NLR does not have independent prognostic significance when the favorable prognostic influence of human papillomavirus (HPV) status is incorporated into multivariate models. Conclusion. The interaction between NLR and HPV status suggests that HPV status may be a determining factor in the favorable prognosis associated with a decreased NLR in HNSCC; these findings also suggest that HPV status may interact with the prognostic associations of indicators of systemic inflammation in HNSCC. (C) 2017 Wiley Periodicals, Inc. [Rosculet, Nicholas] Johns Hopkins Univ, Sch Med, Baltimore, MD USA; [Zhou, Xian Chong] Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA; [Ha, Patrick; Califano, Joseph] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA; [Ha, Patrick; Califano, Joseph] Greater Baltimore Med Ctr, Milton J Dance Jr Head & Neck Ctr, Baltimore, MD USA; [Ha, Patrick] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, Head & Neck Oncol Surg, San Francisco, CA USA; [Tang, Mei; Levine, Marshall A.; Neuner, Geoffrey] Greater Baltimore Med Ctr, Dept Oncol, Baltimore, MD USA; [Levine, Marshall A.] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA; [Califano, Joseph] Univ Calif San Diego, Dept Surg, Div Otolaryngol Head & Neck Surg, San Diego, CA 92103 USA Johns Hopkins University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Johns Hopkins Medicine; Greater Baltimore Medical Center; University of California System; University of California San Francisco; Greater Baltimore Medical Center; Johns Hopkins University; Johns Hopkins Medicine; University of California System; University of California San Diego Califano, J (corresponding author), Univ Calif San Diego, Div Otolaryngol Head & Neck Surg, Dept Surg, Head & Neck Canc Ctr,Moores Canc Ctr, 3855 Hlth Sci Dr,MC 0803, La Jolla, CA 92037 USA. jcalifano@ucsd.edu Acmaz G, 2014, ASIAN PAC J CANCER P, V15, P1689, DOI 10.7314/APJCP.2014.15.4.1689; Chi AC, 2015, CA-CANCER J CLIN, V65, P401, DOI 10.3322/caac.21293; Haddad CR, 2015, J MED IMAG RADIAT ON, V59, P514, DOI 10.1111/1754-9485.12305; Hegde PS, 2016, CLIN CANCER RES, V22, P1865, DOI 10.1158/1078-0432.CCR-15-1507; Kum RO, 2014, ASIAN PAC J CANCER P, V15, P7351, DOI 10.7314/APJCP.2014.15.17.7351; Lawrence MS, 2015, NATURE, V517, P576, DOI 10.1038/nature14129; Li QQ, 2014, ASIAN PAC J CANCER P, V15, P945, DOI 10.7314/APJCP.2014.15.2.945; McNamara MG, 2014, EUR J CANCER, V50, P1581, DOI 10.1016/j.ejca.2014.02.015; Perisanidis C, 2013, MED ONCOL, V30, DOI 10.1007/s12032-012-0334-5; Rachidi S, 2016, HEAD NECK-J SCI SPEC, V38, pE1068, DOI 10.1002/hed.24159; Rassouli A, 2015, HEAD NECK-J SCI SPEC, V37, P103, DOI 10.1002/hed.23567; Tsai YD, 2014, HEAD NECK-J SCI SPEC, V36, P947, DOI 10.1002/hed.23400; Wei Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092079; Wong BYW, 2016, HEAD NECK-J SCI SPEC, V38, pE1903, DOI 10.1002/hed.24346; Xiao WK, 2014, BMC CANCER, V14, DOI 10.1186/1471-2407-14-117; Xue P, 2014, CANCER MED-US, V3, P406, DOI 10.1002/cam4.204 16 31 31 0 4 WILEY HOBOKEN 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 1043-3074 1097-0347 HEAD NECK-J SCI SPEC Head Neck-J. Sci. Spec. Head Neck APR 2017 39 4 662 667 10.1002/hed.24658 http://dx.doi.org/10.1002/hed.24658 6 Otorhinolaryngology; Surgery Science Citation Index Expanded (SCI-EXPANDED) Otorhinolaryngology; Surgery EQ1UV 28075517 2024-02-21 WOS:000397856000008
J Roswall, N; Sandin, S; Adami, HO; Weiderpass, E Roswall, Nina; Sandin, Sven; Adami, Hans-Olov; Weiderpass, Elisabete Cohort Profile: The Swedish Women's Lifestyle and Health cohort INTERNATIONAL JOURNAL OF EPIDEMIOLOGY English Article BREAST-CANCER RISK; ORAL-CONTRACEPTIVE USE; PHYSICAL-ACTIVITY; DIFFERENT PERIODS; YOUNG-WOMEN; PIGMENTARY CHARACTERISTICS; DIETARY PHYTOESTROGENS; SUN EXPOSURE; BODY-SIZE; VITAMIN-D [Roswall, Nina] Danish Canc Soc Res Ctr, Copenhagen, Denmark; [Roswall, Nina; Sandin, Sven; Adami, Hans-Olov; Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, SE-17177 Stockholm, Sweden; [Adami, Hans-Olov] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; [Weiderpass, Elisabete] Canc Registry Norway, Dept Res, Oslo, Norway; [Weiderpass, Elisabete] Univ Tromso, Arctic Univ Norway, Dept Community Med, Fac Hlth Sci, Tromso, Norway; [Weiderpass, Elisabete] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland Danish Cancer Society; Karolinska Institutet; Harvard University; Harvard T.H. Chan School of Public Health; University of Oslo; UiT The Arctic University of Tromso; Folkhalsan Research Center Weiderpass, E (corresponding author), Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, SE-17177 Stockholm, Sweden. Elisabete.Weiderpass.Vainio@ki.se Weiderpass, Elisabete/AAP-2747-2021; Sandin, Sven/L-5357-2015; Weiderpass, Elisabete/M-4029-2016; Roswall, Nina/AAJ-6700-2020 Weiderpass, Elisabete/0000-0003-2237-0128; Sandin, Sven/0000-0001-6994-4884; Weiderpass, Elisabete/0000-0003-2237-0128; Roswall, Nina/0000-0003-3071-1658 Swedish Research Council [521-2011-2955]; The Danish Cancer Society [R91-A6638] Funding Source: researchfish Swedish Research Council(Swedish Research Council); The Danish Cancer Society(Danish Cancer Society) This work was funded by a grant from the Swedish Research Council [Grant number 521-2011-2955]. 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J Ruan, SG Ruan, Shigui Modeling the transmission dynamics and control of rabies in China MATHEMATICAL BIOSCIENCES English Review Mathematical modeling; Transmission dynamics; Rabies; Basic reproduction number; Seasonality; Geographic spread SPATIAL SPREAD; EPIDEMIC MODEL; IMMUNIZATION COVERAGE; INFECTIOUS-DISEASES; SEASONAL-VARIATION; DOGS; THRESHOLD; OUTBREAKS; WILDLIFE; SURVEILLANCE Human rabies was first recorded in ancient China in about 556 BC and is still one of the major public health problems in China. From 1950 to 2015, 130,494 human rabies cases were reported in Mainland China with an average of 1977 cases per year. It is estimated that 95% of these human rabies cases are due to dog bites. The purpose of this article is to provide a review about the models, results, and simulations that we have obtained recently on studying the transmission of rabies in China. We first construct a basic susceptible, exposed, infectious, and recovered (SEIR) type model for the spread of rabies virus among dogs and from dogs to humans and use the model to simulate the human rabies data in China from 1996 to 2010. Then we modify the basic model by including both domestic And stray dogs and apply the model to simulate the human rabies data from Guangdong Province, China. To study the seasonality of rabies, in Section 4 we further propose a SEIR model with periodic transmission rates and employ the model to simulate the monthly data of human rabies cases reported by the Chinese Ministry of Health from January 2004 to December 2010. To understand the spatial spread of rabies, in Section 5 we add diffusion to the dog population in the basic SEIR model to obtain a reaction diffusion equation model and determine the minimum wave speed connecting the disease-free equilibrium to the endemic equilibrium. Finally, in order to investigate how the movement of dogs affects the geographically inter-provincial spread of rabies in Mainland China, in Section 6 we propose a multi-patch model to describe the transmission dynamics of rabies between dogs and humans and use the two-patch submodel to investigate the rabies virus clades lineages and to simulate the human rabies data from Guizhou and Guangxi, Hebei and Fujian, and Sichuan and Shaanxi, respectively. Some discussions are provided in Section 7. (C) 2017 Elsevier Inc. All rights reserved. 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J Rukachaisirikul, T; Chokchaisiri, S; Suebsakwong, P; Suksamrarn, A; Tocharus, C Rukachaisirikul, Thitima; Chokchaisiri, Suwadee; Suebsakwong, Parichat; Suksamrarn, Apichart; Tocharus, Chainarong A New Ajmaline-type Alkaloid from the Roots of Rauvolfia serpentina NATURAL PRODUCT COMMUNICATIONS English Article Rauvolfia serpentina; Apocynaceae; Alkaloids; Anticholinesterase activity; Vasorelaxant activity 400 MHZ H-1-NMR; INDOLE ALKALOIDS; RAUWOLFIA-SERPENTINA; ACID A new ajmaline-type alkaloid, 21-O-methylisoajmaline (1), together with twenty-one known compounds, a mixture of beta-sitosterol (2) and stigmasterol (3), reserpinine (4), tetrahydroalstonine (5), reserpine (6), venoterpine (7), yohimbine (8), 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (9), isoajmaline (10), 3-epi-alpha-yohimbine (11), methyl 3,4,5-trimethoxy-trans-cinnamate (12), a mixture of beta-sitosterol 3-O-beta-D-glucopyranoside (13) and stigmasterol 3-O-beta-D-glucopyranoside (14), rescidine (15), 7-deoxyloganic acid (16), ajmaline (17), suaveoline (18), (+)-tetraphyllicine (19), loganic acid (20), 3-hydroxysarpagine (21), and sarpagine (22), were isolated from the roots of Rauvolfia serpentina. Their structures were elucidated by spectroscopic data analysis and comparison with literature data. Compounds 11, 12 and 15 were for the first time identified from the genus Rauvolfia and 5, 7, 11, 12, 15, 18 and 22 were found from R. serpentina for the first time. Compound 11 showed moderate anticholinesterase activity with IC50 value of 15.58 mu M, whereas 6 exhibited strong vasorelaxant activity with the EC50 value of 0.05 mu M. [Rukachaisirikul, Thitima; Chokchaisiri, Suwadee; Suebsakwong, Parichat; Suksamrarn, Apichart] Ramkhamhang Univ, Dept Chem, Bangkok 10240, Thailand; [Rukachaisirikul, Thitima; Chokchaisiri, Suwadee; Suebsakwong, Parichat; Suksamrarn, Apichart] Ramkhamhang Univ, Ctr Excellence Innovat Chem, Fac Sci, Bangkok 10240, Thailand; [Tocharus, Chainarong] Chiang Mai Univ, Dept Anat, Fac Med, Chiang Mai 50200, Thailand Ramkhamhaeng University; Ramkhamhaeng University; Chiang Mai University Rukachaisirikul, T (corresponding author), Ramkhamhang Univ, Dept Chem, Bangkok 10240, Thailand.; Rukachaisirikul, T (corresponding author), Ramkhamhang Univ, Ctr Excellence Innovat Chem, Fac Sci, Bangkok 10240, Thailand. thitima@ru.ac.th Suksamrarn, Apichart/R-8782-2019 Ramkhamhaeng University; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education; PERCH-CIC Ramkhamhaeng University; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education; PERCH-CIC This work was supported by a fund from Ramkhamhaeng University. Partial support from the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education is gratefully acknowledged. Suwadee thanks PERCH-CIC for a scholarship. 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J Rustemi, O Rustemi, Oriela Letter by Rustemi Regarding Article, Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])"
