Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism

被引：84
|
作者：
Papkalla, A
Münch, J
Otto, C
Kirchhoff, F
机构：
[1] Univ Ulm, Dept Virol, D-89081 Ulm, Germany
[2] Univ Erlangen Nurnberg, Inst Clin & Mol Virol, D-91054 Erlangen, Germany
来源：
JOURNAL OF VIROLOGY | 2002年 / 76卷 / 16期
关键词：
D O I：
10.1128/JVI.76.16.8455-8459.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism.
引用
收藏
页码：8455 / 8459
页数：5
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