CAR-T Related Cytopenia Profile in Relapsed/Refractory Multiple Myeloma: Results of Patients Treated with ARI0002h, an Academic BCMA-Directed CAR-T Cell

被引:1
|
作者
Oliver-Caldes, Aina [1 ]
Gerardo Rodriguez-Lobato, Luis [2 ]
Gonzalez-Calle, Veronica [3 ]
Tovar, Natalia [4 ]
Cabanas, Valentin [5 ]
Rodriguez-Otero, Paula [6 ]
Luis Reguera, Juan [7 ]
Espanol-Rego, Marta [8 ]
Martin-Antonio, Beatriz [9 ]
Zabaleta, Aintzane [10 ]
Lasa, Marta [11 ]
Inoges, Susana [11 ]
Lopez-Diaz de Cerio, Ascension [11 ]
Paiva, Bruno [12 ]
Varea, Sara [13 ]
Saez-Penataro, Joaquin [13 ]
Juan, Manel [8 ]
Rosinol, Laura [14 ]
Prosper, Felipe [15 ]
Moraleda, Jose M. [5 ]
Urbano-Ispizua, Alvaro [16 ]
Pascal, Mariona [8 ]
Mateos, Maria-Victoria [17 ]
Fernandez de Larrea, Carlos [2 ]
机构
[1] Univ Barcelona, Dept Hematol, Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
[2] Hosp Clin Barcelona, Dept Hematol, Amyloidosis & Myeloma Unit, Barcelona, Spain
[3] Hosp Univ Salamanca, Inst Invest Biomed Salamanca IBSAL, Salamanca, Spain
[4] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Amyloidosis & Myeloma Unit, Barcelona, Spain
[5] Univ Murcia, IMIB Arrixaca, Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
[6] Clin Univ Navarra, CIBER ONC, IDISNA, CCUN,CIMA, Pamplona, Navarra, Spain
[7] Univ Seville, Hosp Univ Virgen Rocio CSIC CIBERONC, UGC Hematol, Inst Biomed Sevilla IBiS, Seville, Spain
[8] Univ Barcelona, Dept Immunol, Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
[9] Fdn Jimenez Diaz, Inst Invest Sanitaria, Madrid, Spain
[10] Univ Navarra, Clin Univ Navarra, Ctr Invest Med Aplicada, IDISNA,CIBERONC, Pamplona, Spain
[11] Clin Univ Navarra, Ctr Invest Med Aplicada CIMA, CIBERONC Pamplona, IDISNA, Pamplona, Spain
[12] Clin Univ Navarra, Canc Ctr Univ Navarra CCUN, Ctr Invest Med Aplicada CIMA, Inst Invest Sanitaria Navarra IDISNA, Pamplona, Navarra, Spain
[13] Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, Barcelona, Spain
[14] Hosp Clin Barcelona, IDIBAPS, Dept Hematol, Amyloidosis & Myeloma Unit, Barcelona, Spain
[15] Univ Navarra, Clin Univ Navarra, Ctr Invest Med Aplicada, Pamplona, Spain
[16] Hosp Clin Barcelona, Dept Hematol, Barcelona, Spain
[17] Univ Hosp Salamanca, IBSAL, Canc Res Ctr IBMCC USAL CSIC, Salamanca, Spain
关键词
D O I
10.1182/blood-2022-166525
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:10347 / 10349
页数:3
相关论文
共 50 条
  • [1] Results from a Pilot Study of ARI0002h, an Academic BCMA-Directed CAR-T Cell Therapy with Fractionated Initial Infusion and Booster Dose in Patients with Relapsed and/ or Refractory Multiple Myeloma
    Fernandez de Larrea, Carlos
    Gonzalez-Calle, Veronica
    Cabanas, Valentin
    Oliver-Caldes, Aina
    Espanol-Rego, Marta
    Rodriguez-Otero, Paula
    Luis Reguera, Juan
    Lopez Corral, Lucia
    Inoges, Susana
    Martin-Antonio, Beatriz
    Paiva, Bruno
    Rosinol, Laura
    Lopez-Diaz de Cerio, Ascension
    Tovar, Natalia
    Lopez Parra, Miriam
    Gerardo Rodriguez-Lobato, Luis
    Varea, Sara
    Sanchez Salinas, Andres
    Ortiz-Maldonado, Valentin
    Perez-Simon, Jose A.
    Prosper, Felipe
    Juan, Manel
    Moraleda, Jose Maria
    Mateos, Maria-Victoria
    Pascal, Mariona
    Urbano-Ispizua, Alvaro
    BLOOD, 2021, 138
  • [2] Correlative Biological Studies Related to the Response, Peak and Persistence of ARI0002h, an Academic BCMA-Directed CAR-T Cell, with Fractionated Initial Infusion and Booster Dose for Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)
    Oliver-Caldes, Aina
    Espanol-Rego, Marta
    Zabaleta, Aintzane
    Inoges, Susana
    Lopez-Diaz de Cerio, Ascension
    Gonzalez-Calle, Veronica
    Cabanas, Valentin
    Martin-Antonio, Beatriz
    Perez-Amill, Lorena
    Luis Reguera, Juan
    Roberto Rodriguez-Madoz, Juan
    Rodriguez-Otero, Paula
    Benitez-Ribas, Daniel
    Mena, Mari-Pau
    Lasa, Marta
    Gerardo Rodriguez-Lobato, Luis
    Gonzalez, Azucena
    Rosino, Laura
    Moraleda, Jose Maria
    Prosper, Felipe
    Urbano-Ispizua, Alvaro
    Mateos, Maria-Victoria
    Juan, Manel
    Paiva, Bruno
    Pascal, Marional
    Fernandez de Larrea, Carlos
    BLOOD, 2021, 138
  • [3] Durable Remission Achieved from Bcma-Directed CAR-T Therapy Against Relapsed or Refractory Multiple Myeloma
    Liu, Yarong
    Chen, Zhi
    Fang, Hongliang
    Wei, Runhong
    Yu, Kang
    Jiang, Songfu
    Fu, Weijun
    Jiang, Hua
    Du, Juan
    He, Feng
    Xie, Ronglin
    Chen, Jing
    Wei, Baofeng
    Tao, Jin
    Wang, Pin
    BLOOD, 2018, 132
  • [4] Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma
    Zugas, Ines
    Tormo-Ratera, Marta
    Oliver-Caldes, Aina
    Soler-Perromat, Juan Carlos
    Gonzalez-Calle, Veronica
    Moreno, David F.
    Cabanas, Valentin
    Lopez-Munoz, Nieves
    Bartolome-Solanas, Alvaro
    Espanol-Rego, Marta
    Reguera-Ortega, Juan Luis
    Rosinol, Laura
    Lopez-Corral, Lucia
    Tovar, Natalia
    Rodriguez-Lobato, Luis Gerardo
    Perez, Rosa Maria Alvarez
    Varea, Sara
    Olesti, Eulalia
    Gomez-Grande, Adolfo
    Frutos, Laura
    Tamayo, Pilar
    Juan, Manel
    Moraleda, Jose M.
    Urbano-Ispizua, Alvaro
    Gonzalez-Navarro, E. Azucena
    Martinez-Lopez, Joaquin
    Mateos, Maria-Victoria
    Tomas, Xavier
    Setoain, Xavier
    de Larrea, Carlos Fernandez
    BLOOD ADVANCES, 2025, 9 (03) : 571 - 582
  • [5] Outpatient Reinfusion of CAR-T Cesnicabtagene Autoleucel (ARI0002h) in Multiple Myeloma Is Feasible and Safe
    Munoz, Beatriz Merchan
    Martinez-Roca, Alexandra
    Ballestar, Nuria
    Gallego, Cristina
    Martinez-Cibrian, Nuria
    Ortiz-Maldonado, Valentin
    Rodriguez-Lobato, Luis Gerardo
    Albiol, Nil
    Ayora, Pilar
    Ramos, Carla
    Sanchez-Castanon, Maria
    Juan, Manel
    Delgado, Julio
    Reyner, Jordi Esteve
    Urbano-Ispizua, Alvaro
    Larrea, Carlos Fernandez de
    Fernandez-Aviles, Francesc
    BLOOD, 2024, 144 : 7619 - 7620
  • [6] The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple myeloma
    Rejeski, Kai
    Hansen, Doris K.
    Bansal, Radhika
    Sesques, Pierre
    Ailawadhi, Sikander
    Logue, Jennifer M.
    Braeunlein, Eva
    dos Santos, David M. Cordas M.
    Freeman, Ciara L.
    Alsina, Melissa
    Theurich, Sebastian
    Wang, Yucai
    Krackhardt, Angela M.
    Locke, Frederick L.
    Bachy, Emmanuel
    Jain, Michael D.
    Lin, Yi
    Subklewe, Marion
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2023, 16 (01)
  • [7] Comprehensive Characterization of Prolonged Unexplained Cytopenias in Relapsed/Refractory Multiple Myeloma Patients Following BCMA-Directed CAR-T Cell Therapy
    Thibaud, Santiago
    Mia, Babu
    Van Oekelen, Oliver
    Mouhieddine, Tarek H.
    Schaniel, Christoph
    Ghodke-Puranik, Yogita
    Aleman, Adolfo
    Upadhyaya, Bhaskar
    Lancman, Guido
    Lagana, Alessandro
    Richard, Shambavi
    Rossi, Adriana
    Chari, Ajai
    Sanchez, Larysa
    Rodriguez, Cesar
    Cho, Hearn J.
    Richter, Joshua
    Hoffman, Ronald
    Jagannath, Sundar
    Parekh, Samir
    BLOOD, 2022, 140
  • [8] The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple myeloma
    Kai Rejeski
    Doris K. Hansen
    Radhika Bansal
    Pierre Sesques
    Sikander Ailawadhi
    Jennifer M. Logue
    Eva Bräunlein
    David M. Cordas dos Santos
    Ciara L. Freeman
    Melissa Alsina
    Sebastian Theurich
    Yucai Wang
    Angela M. Krackhardt
    Frederick L. Locke
    Emmanuel Bachy
    Michael D. Jain
    Yi Lin
    Marion Subklewe
    Journal of Hematology & Oncology, 16
  • [9] The CAR-Hematotox Score As a Prognostic Model of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma
    Rejeski, Kai
    Hansen, Doris K.
    Bansal, Radhika
    Sesques, Pierre
    Ailawadhi, Sikander
    Logue, Jennifer M.
    Freeman, Ciara L.
    Alsina, Melissa
    Theurich, Sebastian
    Locke, Frederick L.
    Bachy, Emmanuel
    Jain, Michael D.
    Lin, Yi
    Subklewe, Marion
    BLOOD, 2022, 140 : 7506 - 7508
  • [10] Anti-BCMA CAR-T cell immunotherapy for relapsed or refractory multiple myeloma
    Zhang, Xiaohui
    Ouyang, Chenxi
    Sun, Guofeng
    Liu, Hongfeng
    Qi, Junyuan
    Suo, Xiaohui
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023, 26 (04)