Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: Disease and treatments

被引：53

作者：

Yau, Tung On ^{[1
,2
]}

Tang, Ceen-Ming ^{[1
,2
,3
]}

Yu, Jun ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, LKS Inst Hlth Sci, Dept Med & Therapeut, State Key Lab Digest Dis, Hong Kong, Hong Kong, Peoples R China

[3] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 21期

关键词：

Epstein-Barr virus; Gastric carcinoma; Epigenetic dysregulation; Aberrant DNA methylation; Epigenetic therapies; HISTONE DEACETYLASE INHIBITORS; ISLAND METHYLATOR PHENOTYPE; DNA METHYLTRANSFERASE 1; MEMBRANE-PROTEIN; 2A; PROMOTER HYPERMETHYLATION; CANCER-CELLS; NASOPHARYNGEAL CARCINOMA; ABERRANT METHYLATION; SIGNALING PATHWAY; MICRORNA TARGETS;

D O I：

10.3748/wjg.v20.i21.6448

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) comprises nearly 10% of gastric carcinoma cases worldwide. Recently, it was recognised to have unique clinicopathologic characteristics, including male predominance, lower rates of lymph node involvement, and better prognosis. EBVaGC is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions, causing down-regulation of their expression. In the present review, we critically discuss the role of EBV in gastric carcinogenesis, summarising the role of viral proteins and microRNAs with respect to aberrant methylation in EBVaGC. Given the role of epigenetic dysregulation in tumourigenesis, epigenetic modifiers may represent a novel therapeutic strategy. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：6448 / 6456

页数：9

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