Mechanism of Electro-Oxidation of Metamizole using Cyclic Voltammetry at a Glassy Carbon Electrode

被引:6
|
作者
Bacil, R. P. [1 ]
Buoro, R. M. [1 ]
da Silva, R. P. [1 ]
Medinas, D. B. [1 ]
Lima, A. W. O. [1 ]
Serrano, S. H. P. [1 ]
机构
[1] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, Brazil
关键词
PHARMACEUTICAL FORMULATIONS; DIPYRONE; SODIUM; ANALGESICS; IMMEDIATE; URINE;
D O I
10.1149/1.4704966
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Cyclic Voltammetry at glassy carbon electrode was applied to study the electro-oxidation of Metamizole, a pro-drug largely used in many countries as analgesic which the therapeutic properties are attributed to its hydrolyzed form. Metamizole presents three oxidation processes in aqueous (Britton Robinson Buffer) and DMF media. The first process was characterized as reversible in the last medium. The differentiation between the process associated with the Metamizole and its respective hydrolyzed form the MAA, was investigated and allowed the proposition of a mechanism for the Metamizole electro-oxidation.
引用
收藏
页码:251 / 258
页数:8
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