Radiopharmacokinetic data for Tc-99m-ABP - A new radiopharmaceutical for bone scanning: Comparison with Tc-99m-MDP

Technetium-99m-labeled alendronate is a new radiopharmaceutical for bone scanning developed under strict quality control at the INNSZ, The purpose of this work was to compare the radiopharmacokinetic data and the dosimetry of Tc-99m-ABP and Tc-99m-MDP in 10 volunteers, after it was tested in laboratory animals. Tc-99m-ABP has shorter mean residence time (MRT) and t(1/2) beta; is less protein bound; has a higher renal clearance; smaller Vdss, and similar bone uptake at 1 and 2 h. Tc-99m-ABP gives less radiation exposure to the patient with a 740 MBq dose, and the quality of the bone scan is excellent. Tc-99m-ABP is a better radiopharmaceutical than Tc-99m-MnP for bone scanning. Copyright (C) 1997 Elsevier Science Inc.