Bile acid-induced JNK activation through TGR5 leads to enhanced caspase 8 activation in hepatocytes

被引:0
|
作者
Yoon, Jung-Hwan [1 ]
Kim, Won [1 ]
Gwak, Geum-Youn [1 ]
Lee, Hyo-Suk [1 ]
机构
[1] Seoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
522
引用
收藏
页码:383A / 383A
页数:1
相关论文
共 50 条
  • [1] Bile acid-induced TGR5-dependent c-Jun-N terminal kinase activation leads to enhanced caspase 8 activation in hepatocytes
    Yang, Jong In
    Yoon, Jung-Hwan
    Myung, Sun Jung
    Gwak, Geum-Youn
    Kim, Won
    Chung, Goh Eun
    Lee, Sung Hee
    Lee, Soo-Mi
    Kim, Chung Yong
    Lee, Hyo-Suk
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (01) : 156 - 161
  • [2] The TGR5 receptor mediates bile acid-induced itch and analgesia
    Alemi, Farzad
    Kwon, Edwin
    Poole, Daniel P.
    Lieu, TinaMarie
    Lyo, Victoria
    Cattaruzza, Fiore
    Cevikbas, Ferda
    Steinhoff, Martin
    Nassini, Romina
    Materazzi, Serena
    Guerrero-Alba, Raquel
    Valdez-Morales, Eduardo
    Cottrell, Graeme S.
    Schoonjans, Kristina
    Geppetti, Pierangelo
    Vanner, Stephen J.
    Bunnett, Nigel W.
    Corvera, Carlos U.
    JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (04): : 1513 - 1530
  • [3] The bile acid receptor TGR5 inhibits platelet activation and thrombus formation
    Reusswig, Friedrich
    Reich, Maria
    Wienands, Leonard
    Herebian, Diran
    Keitel-Anselmino, Verena
    Elvers, Margitta
    PLATELETS, 2024, 35 (01)
  • [4] The Role of Bile Acid in the Development of Gastric Adenocarcinoma Via Activation of a Novel Bile Acid Receptor TGR5
    Cao, W.
    Tian, W.
    Hong, J.
    Wang, L. J.
    DeLellis, R.
    Moss, S.
    Resnick, M.
    MODERN PATHOLOGY, 2010, 23 : 139A - 139A
  • [5] Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
    Jadhav, Kavita
    Xu, Yang
    Xu, Yanyong
    Li, Yuanyuan
    Xu, Jiesi
    Zhu, Yingdong
    Adorini, Luciano
    Lee, Yoon Kwang
    Kasumov, Takhar
    Yin, Liya
    Zhang, Yanqiao
    MOLECULAR METABOLISM, 2018, 9 : 131 - 140
  • [6] The Role of Bile Acid in the Development of Gastric Adenocarcinoma Via Activation of a Novel Bile Acid Receptor TGR5
    Cao, W.
    Tian, W.
    Hong, J.
    Wang, L. J.
    DeLellis, R.
    Moss, S.
    Resnick, M.
    LABORATORY INVESTIGATION, 2010, 90 : 139A - 139A
  • [7] TGR5 IS INVOLVED IN BILE ACIDS INDUCED GASTRIC INTESTINAL METAPLASIA THROUGH HNF4A ACTIVATION
    Ni, Zhen
    Lu, Wenquan
    Zeng, Weizheng
    Shi, Yongquan
    GASTROENTEROLOGY, 2020, 158 (06) : S770 - S771
  • [8] Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells
    Kumar, Divya P.
    Rajagopal, Senthilkumar
    Mahavadi, Sunila
    Mirshahi, Faridoddin
    Grider, John R.
    Murthy, Karnam S.
    Sanyal, Arun J.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 427 (03) : 600 - 605
  • [9] Bile Acid Receptor Activation Ameliorates Metabolic Disorders by Differentially Activating FXR or TGR5
    Jadhav, Kavita S.
    Xu, Yang
    Zhang, Yanqiao
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2017, 37
  • [10] Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation
    Iguchi, Yusuke
    Nishimaki-Mogami, Tomoko
    Yamaguchi, Masafumi
    Teraoka, Fumiteru
    Kaneko, Tetsuo
    Une, Mizuho
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2011, 34 (01) : 1 - 7