A common practice in matched case-control studies with incomplete data is to perform two analyses in parallel: a matched analysis of the complete pairs and an unmatched analysis of all subjects carried out after breaking the matching in the complete pairs. The missing-indicator method, which has the advantage of making use of the data in the incomplete pairs while still preserving the matching in the complete pairs, is recommended as an alternative method of analysis, it is shown here that its estimate of the odds ratio is a compromise between the odds ratios estimated by a matched analysis of the complete pairs and an unmatched analysis of the incomplete pairs. The method is illustrated using data from a matched case-control study of the risk of childhood leukemia from exposure to residential electric and magnetic fields.
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Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, NetherlandsUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Groenwold, Rolf H. H.
White, Ian R.
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MRC, Biostat Unit, Cambridge CB2 2BW, EnglandUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
White, Ian R.
Donders, Rogier T.
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Radboud Univ Nijmegen, Dept Epidemiol Biostat & HTA, Med Ctr, NL-6525 ED Nijmegen, NetherlandsUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Donders, Rogier T.
Carpenter, James R.
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London Sch Hyg & Trop Med, Dept Med Stat, London WC1, EnglandUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Carpenter, James R.
Altman, Douglas G.
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Univ Oxford, Ctr Stat Med, Oxford, EnglandUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Altman, Douglas G.
Moons, Karel G. M.
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Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, NetherlandsUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands