Asymmetric Hydrogenation of Imines via Metal-Organo Cooperative Catalysis

被引：26
|
作者：
Tang, Weijun [1 ,2 ]
Xiao, Jianliang [1 ,2 ,3 ]
机构：
[1] Shaanxi Normal Univ, Key Lab Appl Surface & Colloid Chem, Minist Educ, Xian 710062, Peoples R China
[2] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710062, Peoples R China
[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England
来源：
SYNTHESIS-STUTTGART | 2014年 / 46卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
asymmetric hydrogenation; Bronsted acids; iridium; cooperative catalysis; imines; amines; HIGHLY ENANTIOSELECTIVE HYDROGENATION; BRONSTED ACID; REDUCTIVE AMINATION; TRANSITION-METAL; ORGANOCATALYTIC REDUCTION; ALIPHATIC-KETONES; HANTZSCH ESTERS; CYCLIC IMINES; IRIDIUM; LIGANDS;
D O I：
10.1055/s-0033-1338603
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The combination of a chiral phosphoric acid with an iridium complex affords a catalyst that allows for highly enantioselective hydrogenation of imines. Mechanistic studies suggest that the hydrogenation proceeds through a ternary transition state at the hydride-transfer step, in which the organocatalyst interacts with both the hydride donor and acceptor.
引用
收藏
页码：1297 / 1302
页数：6
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