Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity

被引：11
|
作者：
Sagnou, Marina [1 ]
Strongilos, Alexandros [2 ]
Hadjipavlou-Litina, Dimitra [3 ]
Couladouros, Elias A. [4 ]
机构：
[1] NCSR Demokritos, Inst Biol, Athens 15310, Greece
[2] PRO ACTINA SA, Athens, Greece
[3] Aristotle Univ Thessaloniki, Dept Pharmaceut Chem, Sch Pharm, Thessaloniki 54124, Greece
[4] Agr Univ Athens, Chem Labs, Athens 11855, Greece
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 03期
关键词：
Shikonin; Inflammation; Psoriasis; LOX; Radical scavengers; Benzoquinones; 5-LIPOXYGENASE; SHIKONIN; INHIBITORS; INFLAMMATION; DERIVATIVES; ACTIVATION; ALKANNIN; BRAIN;
D O I：
10.2174/157018009787847792
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong. OH radical scavenging, whereas benzoquinones with an hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.
引用
收藏
页码：172 / 177
页数：6
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