Characterization of baseline and treatment-emergent resistance to T-20 (enfuvirtide) observed in Phase II clinical trials: substitutions in gp41 amino acids 36-45 and enfuvirtide susceptibility of virus isolates

被引：0
|
作者：
Sista, P
Melby, T
Greenberg, ML
Davison, D
Jin, L
Moiser, S
Mink, M
Nelson, E
Fang, L
Cammack, N
Salgo, M
Matthews, TJ
机构：
[1] Trimeris Inc, Durham, NC USA
[2] Roche Biosci, Palo Alto, CA USA
[3] Hoffmann La Roche Inc, Nutley, NJ 07110 USA
来源：
ANTIVIRAL THERAPY | 2002年 / 7卷
关键词：
D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
21
引用
收藏
页码：S23 / S23
页数：1
相关论文
共 4 条
  • [1] Impact of HIV-1 gp41 amino acid substitutions (positions 36-45) on susceptibility to T-20 (enfuvirtide) in vitro:: analysis of primary virus isolates recovered from patients during chronic enfuvirtide treatment and site-directed mutants in NL4-3
    Mink, M
    Greenberg, M
    Moiser, S
    Janumpalli, S
    Davison, D
    Jin, L
    Melby, T
    Sista, P
    Lambert, D
    Cammack, N
    Salgo, M
    Matthews, T
    ANTIVIRAL THERAPY, 2002, 7 : S24 - S24
  • [2] Substitutions within HIV gp41 amino acids 36-45 are identified as the primary determinants for loss of in vitro susceptibility to enfuvirtide:: results of data mining analyses of genotypic changes in gp41 in TORO 1 and TORO 2 that associate with changes in phenotypic susceptibility to enfuvirtide
    Su, C
    Heilek-Snyder, G
    Ravindran, P
    Melby, T
    Chiu, S
    Cammack, N
    ANTIVIRAL THERAPY, 2004, 9 (04) : U120 - U121
  • [3] Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates
    Jang, Dai-Ho
    Yoon, Cheol-Hee
    Choi, Byeong-Sun
    Chung, Yoon-Seok
    Kim, Hye-Young
    Chi, Sung-Gil
    Kim, Sung Soon
    JOURNAL OF KOREAN MEDICAL SCIENCE, 2014, 29 (03) : 456 - 459
  • [4] Characterization of envelope glycoprotein gp41 genotype and phenotypic susceptibility to enfuvirtide at baseline and on treatment in the phase III clinical trials TORO-1 and TORO-2
    Melby, T.
    Sista, P.
    DeMasi, R.
    Kirkland, T.
    Roberts, N.
    Salgo, M.
    Heilek-Snyder, G.
    Cammack, N.
    Matthews, T. J.
    Greenberg, M. L.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2006, 22 (05) : 375 - 385
1