Sandmeyer Trifluoromethylation

被引：15
|
作者：
Danoun, Gregory [1 ]
Bayarmagnai, Bilguun [1 ]
Gruenberg, Matthias F. [1 ]
Matheis, Christian [1 ]
Risto, Eugen [1 ]
Goossen, Lukas J. [1 ]
机构：
[1] Tech Univ Kaiserslautern, Dept Chem, D-67663 Kaiserslautern, Germany
来源：
SYNTHESIS-STUTTGART | 2014年 / 46卷 / 17期
关键词：
anilines; copper; Sandmeyer reaction; trifluoromethylation; diazonium salts; NUCLEOPHILIC TRIFLUOROMETHYLATION; FLUORINATION; CHEMISTRY; SALTS;
D O I：
10.1055/s-0034-1378549
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A range of benzotrifluorides are conveniently accessible in high yields from widely available (hetero)aromatic amines and the inexpensive trifluoromethylating agent TMSCF3 through a copper-mediated Sandmeyer trifluoromethylation reaction. Two practical procedures are presented. In the first, the diazonium salts are preformed in an extra reaction step, in the second approach the diazotization and the trifluoromethylation are combined into a one-pot procedure.
引用
收藏
页码：2283 / 2286
页数：4
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