A Review of Cutoffs for Nutritional Biomarkers

被引：55

作者：

Raghavan, Ramkripa ^{[1
]}

Ashour, Fayrouz Sakr ^{[2
]}

Bailey, Regan ^{[3
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Baltimore, MD USA

[2] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA

[3] NIH, Off Dietary Supplements, Bldg 10, Bethesda, MD 20892 USA

来源：

ADVANCES IN NUTRITION | 2016年 / 7卷 / 01期

关键词：

cutoffs; nutritional biomarkers; Youden index; ROC curve; nutritional assessment; nutritional surveillance; nutritional deficiency; reference values; SOLUBLE TRANSFERRIN RECEPTOR; OPTIMAL CUT-POINT; RETINOL-BINDING-PROTEIN; IRON-DEFICIENCY; SERUM FERRITIN; YOUDEN INDEX; REFERENCE INTERVALS; OPTIMAL CUTPOINTS; REFERENCE LIMITS; REFERENCE VALUES;

D O I：

10.3945/an.115.009951

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The nutritional status of an individual or population needs to be assessed through valid and reliable biomarkers. Cutoffs generally have an underlying relation to health status and are one of the important quantitative criteria against which biomarker outputs are compared. For this reason, cutoffs are integral for surveys, surveillance, screening, interventions, monitoring, and evaluation. Despite their importance, nutritional biomarker cutoffs have not been adequately addressed in the literature. Furthermore, the field has not reached a consensus on which cutoff to use for each biomarker, and different cutoffs are often used for the same biomarkers in published studies. This review provides a comprehensive overview of cutoffs related to nutritional biomarkers and highlights some of the high- priority research gaps and challenges of using micronutrient case studies.

引用

页码：112 / 120

页数：9

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