Characterization of a new Puumala virus genotype associated with hemorrhagic fever with renal syndrome

被引：7
|
作者：
Bahr, Udo [1 ]
Zeier, Martin [1 ]
Muranyi, Walter [1 ]
机构：
[1] Klinikum Univ Heidelberg, Sekt Nephrol, D-69120 Heidelberg, Germany
来源：
VIRUS GENES | 2006年 / 33卷 / 02期
关键词：
hantavirus; Puumala; genotype; phylogenetic tree; HFRS;
D O I：
10.1007/s11262-005-0061-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Hantavirus serotype Puumala (PUUV) is the etiologic agent of Nephropathia epidemica (NE), a mild variant of Hemorrhagic Fever with Renal Syndrome (HFRS) in Europe, with lethality rates up to 1% among human patients. The serotype PUUV is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. We describe a new, geographically and phylogenetically well-defined pathogenic PUUV sublineage in Southwest Germany (strain Heidelberg/hu) originated from an HFRS patient. The genetic analysis of PUUV strain Heidelberg/hu may contribute in future to better diagnostics, the development of vaccines, and the understanding of the factors that determine hantavirus pathogenesis.
引用
收藏
页码：229 / 234
页数：6
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