Membrane permeability transition as induced by dysfunction of the electron transport chain

被引：0
|
作者：
Chavez, E
Melendez, E
Zazueta, C
ReyesVivas, H
Perales, SG
机构：
来源：
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1997年 / 41卷 / 05期
关键词：
mitochondria; calcium transport; permeability transition; anaerobiosis; cyclosporin A;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The results in this paper indicate that mitochondrial permeability transition is' activated by dysfunction of the respiratory chain caused by anaerobiosis, exhaustion of the oxidative substrate, and antimycin A, in the presence of 100 mu M Ca2+. Membrane damage coincides with the collapse of the electric gradient. The opening of the non-selective pore is prevented by cyclosporin A.
引用
收藏
页码：961 / 968
页数：8
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