Electrochemical Difluoromethylation of Electron-Deficient Alkenes

被引：56
|
作者：
Xu, He-Huan [1 ]
Song, Jinshuai [2 ]
Xu, Hai-Chao [1 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Fujian, Peoples R China
[2] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China
来源：
CHEMSUSCHEM | 2019年 / 12卷 / 13期
基金：
中国国家自然科学基金;
关键词：
alkene difunctionalization; C-H functionalization; difluoromethylation; electrosynthesis; radicals; C-H FUNCTIONALIZATION; TRIFLUOROMETHYLATION; REAGENT; DIFUNCTIONALIZATION; STRATEGIES; CATALYSIS; RADICALS; AMIDES;
D O I：
10.1002/cssc.201803058
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrochemical 1,2-hydroxydifluoromethylation and C-H difluoromethylation of acrylamides were developed by using CF(2)HSO(2)NHNHBoc as the source of the CF2H group. These electricity-powered oxidative alkene functionalization reactions do not need transition-metal catalysts or chemical oxidants. The reaction outcome, 1,2-difuntionalization or C-H functionalization, is determined by the substituents on the amide nitrogen atom of the acrylamides instead of by the reaction conditions.
引用
收藏
页码：3060 / 3063
页数：4
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