Preparation of finely dispersed drugs III. Cyclosporine

被引：9
|
作者：
Joguet, L [1 ]
Matijevic, E [1 ]
机构：
[1] Clarkson Univ, Ctr Adv Mat Proc, Potsdam, NY 13699 USA
来源：
JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2002年 / 250卷 / 02期
关键词：
colloidal cyclosporine; cyclosporine; drug precipitation; nanosized cyclosporine;
D O I：
10.1006/jcis.2001.8137
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Two different precipitation processes are described, which produced dispersions of spherical particles of cyclosporine ranging in diameter from similar to 10 nm to several micrometers. This drug is of interest for its inummosuppressive activity in the antirejection of transplanted organs. The effects of several experimental parameters on the average particles size and uniformity have been investigated. Aging of spherical particles resulted in large crystalline-type aggregates. (C) 2002 Elsevier Science (USA).
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收藏
页码：503 / 506
页数：4
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